I9785
Imidazolo-oxindole PKR inhibitor C16
≥98% (HPLC), RNA-dependent protein kinases (PKR, Eif2ak2) inhibitor
Synonym(s):
6,8-Dihydro-8-(1H-imidazol-5-ylmethylene)-7H-pyrrolo[2,3-g]benzothiazol-7-one
Select a Size
| Size/SKU | Availability | Price |
|---|---|---|
5 mg | Please contact Customer Service for Availability | PLN 464.00 |
25 mg | Please contact Customer Service for Availability | PLN 1,820.00 |
About This Item
Product Name
Imidazolo-oxindole PKR inhibitor C16, ≥98% (HPLC)
assay
≥98% (HPLC)
color
yellow to orange-brown
solubility
DMSO: 12 mg/mL
shipped in
wet ice
storage temp.
−20°C
SMILES string
O=C1NC2=CC=C3C(SC=N3)=C2/C1=C/C4=CNC=N4
InChI
1S/C13H8N4OS/c18-13-8(3-7-4-14-5-15-7)11-9(17-13)1-2-10-12(11)19-6-16-10/h1-6H,(H,14,15)(H,17,18)/b8-3-
InChI key
VFBGXTUGODTSPK-BAQGIRSFSA-N
Application
- to rescue fear memory deficits and restore long-term potentiation (LTP) impairment in mice
- to inhibit the strong induction of interferon stimulated genes (ISGs) after plasmid transfection in HeLa-S3 cells
- to augment eukaryotic translation initiation factor 2 (eIF2) activity[1]
Biochem/physiol Actions
1 of 1
This Item | |||
|---|---|---|---|
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. −20°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −20°C |
| solubility DMSO: 12 mg/mL | solubility DMSO: 10 mg/mL, clear (warmed) | solubility DMSO: 20 mg/mL, clear | solubility DMSO: 20 mg/mL, clear (warmed), H2O: insoluble |
| color yellow to orange-brown | color white to beige | color white to beige | color yellow to yellow-orange |
| shipped in wet ice | shipped in - | shipped in - | shipped in - |
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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