I5771
Interleukin-6 Receptor Soluble Fragment human
recombinant, expressed in Sf21 cells, ≥97% (SDS-PAGE), lyophilized powder
Synonym(s):
IL-6 sR
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| Size/SKU | Availability | Price |
|---|---|---|
25 μg | Please contact Customer Service for Availability | PLN 3,590.00 |
About This Item
Form:
lyophilized powder
Assay:
≥97% (SDS-PAGE)
Recombinant:
expressed in Sf21 cells
PLN 3,590.00
Please contact Customer Service for Availability
recombinant
expressed in Sf21 cells
Quality Segment
assay
≥97% (SDS-PAGE)
form
lyophilized powder
impurities
endotoxin, tested
storage temp.
−20°C
General description
Interleukin-6 is a pleotropic cytokine involved in hematopoiesis, inflammation and immune response. IL-6 is secreted by macrophages, dendritic cells and B cells, in response to TNF-α, PGDF and IL-1. The signaling by IL-6 is mediated by heterodimeric receptor, IL-6R, comprising of IL-6Rα (soluble factor) and gp130 (sometimes called IL-6Rβ). Gp130 is crucial component for downstream signal transduction. In response to IL-6, gp130 activates kinases of JAK family, STATs, MAPK and Ras proteins. [1][2][3] IL-6R-mediated signaling is essential for normal development of T and B cells [4] and has been implicated in many diseases such as rheumatoid arthritis, Crohn disease, sepsis, fever, systemic lupus erythematosus, osteoporosis and insulin resistance[2][5][6][7]
Interleukin-6 Receptor soluble fragment specifically binds and inhibits the activity of human IL-6 in free form or when bound to cell surface receptors.
Interleukin-6 Receptor soluble fragment specifically binds and inhibits the activity of human IL-6 in free form or when bound to cell surface receptors.
Application
Interleukin-6 Receptor soluble fragment elicits a 50% increase in IL-6 activity in cell based assay at a concentration (EC50) of 1-10 ng/ml.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 1.25 mg bovine serum albumin.
Analysis Note
The receptor mediated activity of human IL-6 receptor soluble fragment is measured by its ability to increase the IL-6 inhibition of M1 cells.[8]
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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This Item | |||
|---|---|---|---|
| recombinant expressed in Sf21 cells | recombinant - | recombinant expressed in CHO cells | recombinant expressed in E. coli |
| assay ≥97% (SDS-PAGE) | assay ≥97% (SDS-PAGE) | assay ≥95% (HPLC), ≥95% (SDS-PAGE) | assay ≥95% (SDS-PAGE) |
| form lyophilized powder | form lyophilized | form lyophilized | form lyophilized |
| impurities endotoxin, tested | impurities ≤1 EU/μg Endotoxin | impurities <1 EU/μg endotoxin, tested | impurities ≤1 EU/μg endotoxin, tested |
| storage temp. −20°C | storage temp. −70°C | storage temp. −20°C | storage temp. -10 to -25°C |
| Quality Level 100 | Quality Level 100 | Quality Level - | Quality Level 300 |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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