I0281

Interleukin-4/Fc Chimera (non-lytic) from mouse

>98% (SDS-PAGE), recombinant, expressed in CHO cells, buffered aqueous solution

• Synonym(s): IL-4:Fc (non-lytic)
• UNSPSC Code: 51111800
• NACRES: NA.32
• MDL number: MFCD03457249

Properties

• biological source: mouse
• recombinant: expressed in CHO cells
• assay: >98% (SDS-PAGE)
• form: buffered aqueous solution
• mol wt: 98 kDa
• packaging: pkg of 10 μg
• impurities: endotoxin, tested
• UniProt accession no.: P07750
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: mouse ... Il4(16189)

Description

Biochem/physiol Actions

In mice, absence of IL-4 (interleukin-4) causes anxiety-like behavior. It is secreted by Th2 (T helper) cells and works as a pro-inflammatory cytokine. It plays an important role in immune response and allergic diseases. It is also associated with schistosoma mansoni pulmonary hypertension.

Possesses the biological functions of the IL-4 moiety and a prolonged circulating half-life determined by the Fc domain.

Physical form

Solution in 0.2 μm filtered phosphate buffered saline, pH 7.4.

Other Notes

Dimeric fusion protein consisting of mouse IL-4 fused to mutant mouse Fcγ2a Fc.