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H4632

Hemoglobin equine

lyophilized powder

Synonym(s):

Hb

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Size/SKUAvailabilityPrice
10 g
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PLN 3,380.00

About This Item

CAS Number:
9047-09-0
UNSPSC Code:
12352202
NACRES:
NA.61
MDL number:
MFCD00131282
Form:
lyophilized powder
Biological source:
horse

PLN 3,380.00

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biological source

horse

Quality Segment

200

form

lyophilized powder

technique(s)

protein quantification: suitable

solubility

H2O: soluble 10 mg/mL

UniProt accession no.

P01958, P02062

storage temp.

2-8°C

Gene Information

horse ... HBA(100036557), HBB(100054109)

General description

Hemoglobin is the major component of red blood cells and is responsible for their red color. Its normal concentration in erythrocytes is 34%. The structure of horse hemoglobin was elucidated first.[1] It comprises heme (iron protoporphyrin IX group) and four polypeptide chains. The fetal and adult hemoglobin of horse are structurally identical.[2]

Application

Hemoglobin equine has been used as a standard protein:
  • to test solid-film sampling methodology in Fourier transform infrared spectroscopy (FT-IR) for protein secondary structure determination[3]
  • in capillary reversed-phase liquid chromatography-tandem mass spectrometry (LC/MS/MS) post enzymatic digestion[4]
  • for quantification of hemoglobin content from the planktonic crustacean, Daphnia magna[5]

Biochem/physiol Actions

Hemoglobin is the most important respiratory protein of vertebrates by its ability to transport oxygen from the lungs to body tissues and to facilitate the return transport of carbon dioxide.[1] The ferrous-ferric (Fe2+/Fe3+) balance is a physiological indicator of blood oxygenation.[1] Deoxygenated hemoglobin accessorizes a feedback loop by reducing nitrite to nitric oxide (NO), a vasodilator which enhances blood flow to oxygen-deprived tissues.[6] The fetal and adult hemoglobin from horse display differences in their affinity towards 2,3-diphosphoglycerate (2,3-DPG).[2] Mutation in the globin gene is implicated in sickle cell anemia.[1]
Oxygen transporter, NO scavenger

Disclaimer

Since native hemoglobin is readily oxidized in air, these preparations may be predominantly methemoglobin.

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Hemoglobin equine lyophilized powder

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Hemoglobin from bovine blood

Hemoglobin human lyophilized powder

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H7379

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Hemoglobin S, Ferrous Stabilized human lyophilized powder

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H0392

Hemoglobin S, Ferrous Stabilized human

technique(s)

protein quantification: suitable

technique(s)

activity assay: suitable

technique(s)

enzyme immunoassay: suitable

technique(s)

electrophoresis: suitable, immunofluorescence: suitable

biological source

horse

biological source

bovine blood

biological source

human

biological source

human

form

lyophilized powder

form

substrate powder

form

lyophilized powder

form

lyophilized powder

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

UniProt accession no.

P01958, P02062

UniProt accession no.

P01966, P02070, P02081, P06642, P06643

UniProt accession no.

P02008, P02042, P02100, P09105, P68871, P69891, P69892, P69905

UniProt accession no.

P68871

Gene Information

horse ... HBA(100036557), HBB(100054109)

Gene Information

cow ... HBA1(281221), HBB(280813), HBE2(513240), HBE4(513108), HBG(511735), alpha globin(512439)

Gene Information

human ... HBA1(3039), HBA2(3040), HBB(3043), HBD(3045), HBE1(3046), HBG1(3047), HBG2(3048), HBQ1(3049), HBZ(3050)

Gene Information

human ... HBB(3043)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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