G5918

GR 113808

≥98% (HPLC), solid

• Synonym(s): 1-[2-[(Methylsulfonyl)-amino]ethyl]-4-piperidinyl]methyl 1-methyl-1H-indole-3-carboxylate
• Empirical Formula (Hill Notation): C₁₉H₂₇N₃O₄S
• CAS Number: 144625-51-4
• Molecular Weight: 393.50
• NACRES: NA.77
• PubChem Substance ID: 24278311
• UNSPSC Code: 12352200
• MDL number: MFCD00912901
• Assay: ≥98% (HPLC)
• Form: solid

Properties

• Quality Segment: 200
• assay: ≥98% (HPLC)
• form: solid
• color: white to light pink
• solubility: DMSO: >20 mg/mL
• originator: GlaxoSmithKline
• storage temp.: 2-8°C
• SMILES string: Cn1cc(C(=O)OCC2CCN(CCNS(C)(=O)=O)CC2)c3ccccc13
• InChI: 1S/C19H27N3O4S/c1-21-13-17(16-5-3-4-6-18(16)21)19(23)26-14-15-7-10-22(11-8-15)12-9-20-27(2,24)25/h3-6,13,15,20H,7-12,14H2,1-2H3
• InChI key: MOZPSIXKYJUTKI-UHFFFAOYSA-N
• Gene Information: human ... HTR4(3360) ; rat ... Htr3a(79246), Htr4(25324)

Description

Application

GR 113808 has been used as a serotonin receptor 4 (5-HT4R) blocker to study its effects on the calcium (Ca²⁺) transients in rat ventricular cardiomyocytes.[1] It has also been used as a 5-HT4R antagonist to study its effects on de novo enteric neurogenesis in post-embryonic zebrafish.[2]

Biochem/physiol Actions

GR 113808 is a 5-HT₄ serotonin receptor antagonist.

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold for research purposes under agreement from Glaxo­Smith­Kline

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)