E3256
Edrophonium chloride
Synonym(s):
Ethyl(m-hydroxyphenyl)dimethylammonium chloride
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About This Item
Empirical Formula (Hill Notation):
C10H16ClNO
CAS Number:
Molecular Weight:
201.69
EC Number:
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
SMILES string
[Cl-].CC[N+](C)(C)c1cccc(O)c1
InChI
1S/C10H15NO.ClH/c1-4-11(2,3)9-6-5-7-10(12)8-9;/h5-8H,4H2,1-3H3;1H
InChI key
BXKDSDJJOVIHMX-UHFFFAOYSA-N
Gene Information
human ... ACHE(43)
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Biochem/physiol Actions
Acetycholinesterase inhibitor
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Ulrike Schara et al.
Neuropediatrics, 43(4), 184-193 (2012-08-23)
Congenital myasthenic syndromes (CMS) are rare genetically and clinically heterogeneous disorders characterized by an impaired neuromuscular transmission. Exact prevalence data are not available, approximately 2000 to 3000 patients worldwide have been diagnosed on a molecular level; mutations in 14 different
Hariprasad Korsapati et al.
Gastroenterology, 135(3), 796-802 (2008-08-05)
Patients with high-amplitude esophageal contractions (nutcracker esophagus [NCE]) show asynchrony of circular muscle (CM) and longitudinal muscle (LM) contraction during peristalsis. The goal of our study was to determine if this asynchrony is related to an increase in the cholinergic
Leonardo Pisani et al.
ChemMedChem, 5(9), 1616-1630 (2010-08-03)
A large series of substituted coumarins linked through an appropriate spacer to 3-hydroxy-N,N-dimethylanilino or 3-hydroxy-N,N,N-trialkylbenzaminium moieties were synthesized and evaluated as acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors. The highest AChE inhibitory potency in the 3-hydroxy-N,N-dimethylanilino series was observed with a
John J Savarese et al.
Anesthesiology, 113(1), 58-73 (2010-06-08)
The ultra-short-acting neuromuscular blocker gantacurium is chemically degraded in vitro by rapid adduction of L-cysteine to its central olefinic double bond. Preliminary data have suggested that exogenous (intravenous) L-cysteine abolishes gantacurium blockade. Two new analogues of gantacurium (CW 002 and
Manuel Martin-Flores et al.
Journal of the American Animal Hospital Association, 47(4), 294-298 (2011-06-16)
A case of prolonged muscle relaxation after vecuronium in an anesthetized dog is presented. After using peripheral nerve stimulation to confirm partial recovery of neuromuscular transmission, administration of 0.5 mg/kg IV of intravenous edrophonium failed to complete the reversal process.
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