E1127

β-Estradiol 17-(β-D-glucuronide) sodium salt

≥98% (HPLC), Estradiol metabolite, powder

• Synonym(s): 1,3,5(10)-Estratriene-3,17β-diol 17-glucuronide, 3,17β-Dihydroxy-1,3,5(10)-estratriene 17-glucuronide
• Linear Formula: C₂₄H₃₁O₈Na
• CAS Number: 15087-02-2
• Molecular Weight: 470.49
• UNSPSC Code: 51111800
• PubChem Substance ID: 24894388
• NACRES: NA.77
• MDL number: MFCD00056557
• Assay: ≥98% (HPLC)
• Form: powder
• Quality level: 200

Properties

• Product Name: β-Estradiol 17-(β-D-glucuronide) sodium salt,
• sterility: non-sterile
• Quality Level: 200
• assay: ≥98% (HPLC)
• form: powder
• solubility: 0.1 M NaOH: 10 mg/mL, clear to slightly hazy, colorless to faintly yellow
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: [Na].CC12CCC3C(CCc4cc(O)ccc34)C1CCC2OC5OC(C(O)C(O)C5O)C(O)=O
• InChI: 1S/C24H32O8.Na.H/c1-24-9-8-14-13-5-3-12(25)10-11(13)2-4-15(14)16(24)6-7-17(24)31-23-20(28)18(26)19(27)21(32-23)22(29)30;;/h3,5,10,14-21,23,25-28H,2,4,6-9H2,1H3,(H,29,30);;
• InChI key: GPLPNZUTAJWRLU-UHFFFAOYSA-N

Description

Application

β-Estradiol 17-(β-D-glucuronide) sodium salt has been used as a standard to determine the quantity of β-Estradiol 17-(β-D-glucuronide) during UDP-glucuronosyltransferase assay. It has also been used as a constituent of modified synthetic oviduct fluid (m-SOF) for maturation of bovine cumulus oocyte complexes (COC).

Biochem/physiol Actions

Estradiol 17-(β-D-glucuronide) (E217G) is a naturally occurring conjugated estrogen. It is formed in the liver and later excreted in bile. Increased concentrations of E217G leads to the development of cholestasis during the later stages of pregnancy, a condition which occurs with high frequency in the Dubin-Johnson syndrome.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Safety Information

• pictograms: GHS08,GHS07
• signalword: Warning
• hcodes: H302 + H312 + H332,H351
• pcodes: P202 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• ppe: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges