D0540

DNQX

Name: DNQX
Brand: SIGMA
Price: 428 PLN

≥98% (TLC), kainate, quisqualate (non-NMDA) glutamate receptor antagonist, powder

Synonym(s):

6,7-Dinitroquinoxaline-2,3(1H,4H)-dione

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PLN 428.00

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PLN 996.00

PLN 428.00

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About This Item

Empirical Formula (Hill Notation):

C₈H₄N₄O₆

CAS Number:

2379-57-9

Molecular Weight:

252.14

UNSPSC Code:

51111800

PubChem Substance ID:

24277973

NACRES:

NA.77

MDL number:

MFCD00069257

Assay:

≥98% (TLC)

Form:

powder

Quality level:

200

Key Documents

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Product Name

DNQX, ≥98% (TLC)

SMILES string

[O-][N+](=O)c1cc2NC(=O)C(=O)Nc2cc1[N+]([O-])=O

InChI key

RWVIMCIPOAXUDG-UHFFFAOYSA-N

InChI

1S/C8H4N4O6/c13-7-8(14)10-4-2-6(12(17)18)5(11(15)16)1-3(4)9-7/h1-2H,(H,9,13)(H,10,14)

assay

≥98% (TLC)

form

powder

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This Item	C127	C239	B3188
Sigma-Aldrich D0540 DNQX	Sigma-Aldrich C127 CNQX	Sigma-Aldrich C239 CNQX disodium salt hydrate	Sigma-Aldrich B3188 BYK204165
assay ≥98% (TLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
form powder	form solid	form solid	form powder
Quality Level 200	Quality Level 100	Quality Level 100	Quality Level 100
Gene Information human ... GRIA1(2890), GRIA2(2891), GRIK1(2897), GRIK2(2898), GRIK3(2899), GRIK4(2900), GRIK5(2901) mouse ... Gria1(14799) rat ... Gria1(50592), Grik1(29559), Grik4(24406), Grin2a(24409)	Gene Information rat ... Gria1(50592), Grik1(29559), Grik2(54257), Grik4(24406), Grin2a(24409)	Gene Information human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140), GRIA1(2890), GRIA2(2891), GRIA3(2892), GRIA4(2893)	Gene Information human ... PARP1(142) mouse ... PARP1(11545) rat ... PARP1(25591)

Application

DNQX has been used to block N-Methyl-D-aspartic acid (NMDA) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in various experiments.[1][2][3]

Biochem/physiol Actions

A competitive kainate, quisqualate (non-NMDA) glutamate receptor antagonist.

DNQX is a quinoxaline derivative.[4]

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Focal activation of neuronal circuits induced by microstimulation in the visual cortex

Tanaka Y, et al.

Journal of Neural Engineering, 16(3), 036007-036007 (2019)

Genetically driven brain serotonin deficiency facilitates panic-like escape behavior in mice.

J Waider et al.

Translational psychiatry, 7(10), e1246-e1246 (2017-10-04)

Multiple lines of evidence implicate brain serotonin (5-hydroxytryptamine; 5-HT) system dysfunction in the pathophysiology of stressor-related and anxiety disorders. Here we investigate the influence of constitutively deficient 5-HT synthesis on stressor-related anxiety-like behaviors using Tryptophan hydroxylase 2 (Tph2) mutant mice.

The cooperation of sustained and phasic inhibitions increases the contrast of ITD-tuning in low-frequency neurons of the chick nucleus laminaris.

Rei Yamada et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(9), 3927-3938 (2013-03-01)

Neurons in the nucleus laminaris (NL) of birds detect the coincidence of binaural excitatory inputs from the nucleus magnocellularis (NM) on both sides and process the interaural time differences (ITDs) for sound localization. Sustained inhibition from the superior olivary nucleus

The mouse pulvinar nucleus links the lateral extrastriate cortex, striatum, and amygdala

Zhou N, et al.

The Journal of Neuroscience, 38(2), 347-362 (2018)

Optogenetic Mapping of Intracortical Circuits Originating from Semilunar Cells in the Piriform Cortex.

Julian M C Choy et al.

Cerebral cortex (New York, N.Y. : 1991), 27(1), 589-601 (2015-10-28)

Despite its comparatively simple trilaminar architecture, the primary olfactory (piriform) cortex of mammals is capable of performing sophisticated sensory processing, an ability that is thought to depend critically on its extensive associational (intracortical) excitatory circuits. Here, we used a novel

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