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D002

Sigma-Aldrich

(±)-2-Amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene hydrobromide

solid

Synonym(s):

6,7-ADTN hydrobromide

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About This Item

Empirical Formula (Hill Notation):
C10H13NO2 · HBr
CAS Number:
13575-86-5
Molecular Weight:
260.13
MDL number:
MFCD00036982
UNSPSC Code:
12352200
PubChem Substance ID:
24277893

form

solid

storage condition

protect from light

solubility

H2O: >10 mg/mL (Dissolve in oxygen-free water containing 0.1% sodium metabisulfite or other antioxidants.)
aqueous base: unstable

storage temp.

2-8°C

SMILES string

Br[H].NC1CCc2cc(O)c(O)cc2C1

Gene Information

human ... DRD1(1812) , DRD2(1813) , DRD3(1814) , DRD4(1815) , DRD5(1816)

Biochem/physiol Actions

Dopamine receptor agonist.

Caution

Air- and light-sensitive

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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K S Sugamori et al.
FEBS letters, 362(2), 131-138 (1995-04-03)
We report here the isolation from Drosophila melanogaster of a 2.0 kb cDNA clone encoding a 385 amino acid protein (dDA1) displaying, within putative transmembrane domains, highest amino acid sequence homology (49-53%) to members of the vertebrate dopamine D1-like receptor
B H Rohde et al.
Current eye research, 8(12), 1225-1231 (1989-12-01)
A binding site for tritiated 2-amino-6, 7-dihydroxy-1, 2,3,4-tetrahydronaphthalene (ADTN) has been partially characterized in the rabbit iris root-ciliary body. Binding of ADTN is proportional to protein content and requires at least 60 minutes to reach equilibrium. Binding is saturable, with
Regan Ashby et al.
Experimental eye research, 85(1), 15-22 (2007-05-15)
Increases in the expression of the immediate early gene ZENK in the retina, measured by changes in the levels of mRNA and protein immunoreactivity, are amongst the most rapid responses so far measured to conditions that decrease the rate of
S Patel et al.
Behavioral neuroscience, 102(4), 596-600 (1988-08-01)
The effects of administration of gamma-aminobutyric acid (GABA) compounds into the ventral pallidum and substantia innominata on the locomotor hyperactivity induced by the dopamine agonist 2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene (ADTN) in the nucleus accumbens were investigated in rats. Hyperactivity induced by ADTN was
A J Balmforth et al.
Journal of neurochemistry, 51(5), 1510-1515 (1988-11-01)
3,4-Dihydroxyphenylethylamine (dopamine) and beta-adrenergic receptor agonists and antagonists were assessed for their effects on cyclic AMP accumulation in human astrocytoma derived clone D384 cells. Dopamine, SKF 38393, and 2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene increased cyclic AMP content with Ka values of 2.0, 0.2, and
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