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| Size/SKU | Availability | Price |
|---|---|---|
5 mg | Please contact Customer Service for Availability | PLN 690.00 |
25 mg | Please contact Customer Service for Availability | PLN 2,760.00 PLN 2,346.00 |
About This Item
Empirical Formula (Hill Notation):
C15H11Cl2NOS
CAS Number:
Molecular Weight:
324.22
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.25
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Product Name
CGP-37157, ≥98% (HPLC), powder
assay
≥98% (HPLC)
form
powder
color
white
solubility
DMSO: ≥20 mg/mL
storage temp.
2-8°C
SMILES string
Clc1ccc2NC(=O)CSC(c3ccccc3Cl)c2c1
InChI
1S/C15H11Cl2NOS/c16-9-5-6-13-11(7-9)15(20-8-14(19)18-13)10-3-1-2-4-12(10)17/h1-7,15H,8H2,(H,18,19)
InChI key
KQEPIRKXSUIUTH-UHFFFAOYSA-N
General description
CGP-37157 is a benzothiazepine compound, which is derived from clonazepam. It functions as a sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) antagonist and ryanodine receptor channels (RyR) agonist. CGP-37157 regulates intracellular signaling of calcium in smooth, cardiac and skeletal muscle cells and non-muscle systems.
Application
CGP-37157 has been used as a mitochondrial sodium-calcium exchanger (mNCX) inhibitor to study the role of normal mitochondrial calcium dynamics in sustaining dendritic spinogenesis.
Biochem/physiol Actions
Specific inhibitor of mitochondrial Na+/Ca2+ exchange as well as sarcoplasmic reticulum calcium-stimulated ATPase and possibly other calcium channels.
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This Item | |||
|---|---|---|---|
| assay ≥98% (HPLC) | assay ≥98% (TLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| form powder | form powder | form powder | form powder |
| Quality Level 100 | Quality Level 200 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. - | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility DMSO: ≥20 mg/mL | solubility 2-hydroxypropyl-β-cyclodextrin: insoluble, H2O: insoluble | solubility DMSO: >2 mg/mL (warmed) | solubility DMSO: 2 mg/mL, clear |
| color white | color - | color light yellow to light brown | color white to beige |
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Storage Class
11 - Combustible Solids
wgk
WGK 3
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