C5688
Complement factor D from human plasma
90-110 μg/mL in PBS, pH 7.2, ≥90% (SDS-PAGE)
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| Size/SKU | Availability | Price |
|---|---|---|
10 μg | Please contact Customer Service for Availability | PLN 1,700.00 PLN 1,445.00 |
About This Item
Form:
liquid
Assay:
≥90% (SDS-PAGE)
Biological source:
human plasma
PLN 1,445.00
List PricePLN 1,700.00Save 15%Please contact Customer Service for Availability
Application
Complement factor D is a serine protease essential for the activation of the alternative pathway in the complement system. Research of complement factor D has revealed that a self inhibitory loop is responsible for switch from a resting to active state. Additionally, recent research has linked a complement factor D gene, single nucleotide polymorphism (SNP) rs3826945, with age-related macular degeneration (AMD). In these AMD cases there was a significant increase in plasma complement factor D concentration, even though previous research has shown no association between complement factor D SNP genes and AMD.
Biochem/physiol Actions
Complement factor D is a serine protease with structural homologies with chymotrypsin. In the complement cascade, factor D cleaves complement factor B in complex with activated complement component C3. It is identical to adipsin, which is expressed in adipose tissue.
Analysis Note
Source plasma tested for HBSAg, HCV, HBC, syphillis, and HIV-1/HIV-2
Other Notes
View more information on the complement pathway at www.sigma-aldrich.com/enzymeexplorer
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
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This Item | |||
|---|---|---|---|
| assay ≥90% (SDS-PAGE) | assay ≥90% (SDS-PAGE) | assay ≥85% (SDS-PAGE) | assay ≥90% (SDS-PAGE) |
| biological source human plasma | biological source human plasma | biological source human serum | biological source human serum |
| concentration 90-110 μg/mL in PBS, pH 7.2 | concentration 1 mg/mL in PBS, pH 7.2 | concentration 1 mg/mL in 10 mM sodium phosphate, 150 mM sodium chloride, pH 7.2 | concentration 1 mg/mL in PBS, pH 7.2 |
| form liquid | form liquid | form solution | form solution |
| UniProt accession no. | UniProt accession no. | UniProt accession no. | UniProt accession no. |
| Gene Information human ... CFD(1675) | Gene Information human ... CFH(3075) | Gene Information human ... C7(730) | Gene Information human ... C5(727) |
Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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