C2917
Corticotropin Releasing Factor Antagonist
≥97% (HPLC)
Synonym(s):
α-Helical CRF (9-41), α-Helical corticotropin releasing factor fragment (9-41)
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| Size/SKU | Availability | Price |
|---|---|---|
0.1 mg | Please contact Customer Service for Availability | PLN 630.00 |
About This Item
Empirical Formula (Hill Notation):
C166H274N46O53S2
CAS Number:
Molecular Weight:
3826.36
UNSPSC Code:
51111800
NACRES:
NA.32
MDL number:
Quality Segment
assay
≥97% (HPLC)
form
powder
storage temp.
−20°C
Gene Information
human ... CRH(1392)
mouse ... CRH(12918)
rat ... CRH(81648)
Biochem/physiol Actions
Exhibits 10-fold higher affinity for rat CRF2α receptors over human CRF2α receptors.
The corticotropin releasing factor (CRF) antagonist α-helical CRF [9-41] exhibits 10-fold higher affinity for rat CRF2α receptors over human CRF2α receptors. It has been used to elucidate the role of CRF in various physiological systems. In colonic epithelium, it abolishes CRF-induced changes in ion secretion, and significantly inhibits CRF-stimulated conductance. It antagonizes the CRF-induced proinflammatory degranulation of perivascular mast cells that are activated in response to acute psychological stress and CRF secretion.
Other Notes
Lyophilized from 0.1% TFA in H2O
1 of 1
This Item | |||
|---|---|---|---|
| assay ≥97% (HPLC) | assay ≥95% (HPLC) | assay ≥95% (HPLC) | assay ≥90% (HPLC) |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| form powder | form powder | form powder | form powder |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| Gene Information human ... CRH(1392) | Gene Information human ... CRH(1392) | Gene Information - | Gene Information human ... CRH(1392) |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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