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C1835

(S)-(+)-4-Carboxyphenylglycine

Synonym(s):

(S)-α-Amino-4-carboxyphenylacetic acid, L-α-(4-Carboxyphenyl)glycine, S-4CPG

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About This Item

Empirical Formula (Hill Notation):
C9H9NO4
CAS Number:
134052-73-6
Molecular Weight:
195.17
UNSPSC Code:
12352103
MDL number:
MFCD00216831
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solubility

0.1 M NaOH: 15 mg/mL

Biochem/physiol Actions

Competitive mGluR1 metabotropic glutamate receptor antagonist; mGluR2 metabotropic glutamate receptor agonist.

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Certificates of Analysis (COA)

Lot/Batch Number
089H1383
026H0148

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Pharmacological analysis of carboxyphenyl-glycines at metabotropic glutamate receptors.
Cavanni, et al.
Eur. J. Pharmacol., Molec. Pharmacol. Sec., 269, 9-9 (1994)
S A Eaton et al.
European journal of pharmacology, 244(2), 195-197 (1993-01-15)
Two phenylglycine derivates, (S)-4-carboxyphenylglycine and (RS)-alpha-methyl-4-carboxyphenylglycine, competitively antagonised (1S,3R)-1-aminocyclopentane-1,3-dicarboxylate (ACPD)-stimulated phosphoinositide hydrolysis in rat cerebral cortical slices. The same phenylglycine derivatives selectively antagonized ACPD-induced depolarization in neonatal rat spinal motoneurones and rate thalamic neurones relative to depolarization or excitation induced
E F Birse et al.
Neuroscience, 52(3), 481-488 (1993-02-01)
The possible roles of G-protein coupled metabotropic glutamate receptors in central nervous function are currently the focus of intensive investigation. The complexity of effects produced by agonists at these receptors probably reflects the activity of a range of sub-types. The