C124

β-CFT naphthalenedisulfonate monohydrate

solid

• Synonym(s): (−)-2-β-Carbomethoxy-3-β-(4-fluorophenyl)tropane 1,5-naphthalenedisulfonate monohydrate, WIN 35,428 naphthalenedisulfonate monohydrate
• Empirical Formula (Hill Notation): C₁₆H₂₀FNO₂ · C₁₀H₈O₆S₂ · H₂O
• CAS Number: 77210-32-3
• Molecular Weight: 583.65
• NACRES: NA.77
• PubChem Substance ID: 24892389
• UNSPSC Code: 12352200
• MDL number: MFCD11044874
• Form: solid
• Quality level: 100

Properties

• form: solid
• Quality Level: 100
• optical activity: [α]25/D −62.5°, c = 1.0 in H₂O(lit.)
• drug control: USDEA Schedule II
• color: white
• solubility: H₂O: soluble
• storage temp.: 2-8°C
• SMILES string: O.OS(=O)(=O)c1cccc2c(cccc12)S(O)(=O)=O.COC(=O)[C@@H]3C4CCC(C[C@@H]3c5ccc(F)cc5)N4C
• InChI: 1S/C16H20FNO2.C10H8O6S2.H2O/c1-18-12-7-8-14(18)15(16(19)20-2)13(9-12)10-3-5-11(17)6-4-10;11-17(12,13)9-5-1-3-7-8(9)4-2-6-10(7)18(14,15)16;/h3-6,12-15H,7-9H2,1-2H3;1-6H,(H,11,12,13)(H,14,15,16);1H2/t12-,13+,14+,15-;;/m0../s1
• InChI key: XSJPWVYASBDEJI-YEVYTSHMSA-N

Description

Biochem/physiol Actions

Cocaine analog that inhibits the dopamine, norepinephrine, and serotonin transporters with K_is of 26.1 nM, 31.9 nM, and 127 nM, respectively. [¹¹C]-β-CFT and [¹⁸F]-β-CFT are ligands for PET imaging of the dopamine transporter in vivo.

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• pictograms: GHS06,GHS08
• signalword: Danger
• hcodes: H300 + H310 + H330,H317,H361
• pcodes: P202 - P260 - P264 - P280 - P302 + P352 + P310 - P304 + P340 + P310
• Hazard Classifications: Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Repr. 2 - Skin Sens. 1
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk: WGK 3
• ppe: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges