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Merck

C121

7-Chlorokynurenic acid

solid

Synonym(s):

7-Chloro-4-hydroxyquinoline-2-carboxylic acid, 7-Cl-KYNA

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About This Item

Empirical Formula (Hill Notation):
C10H6ClNO3
CAS Number:
18000-24-3
Molecular Weight:
223.61
UNSPSC Code:
12352200
EC Number:
241-913-6
MDL number:
MFCD00069227

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form

solid

color

tan

solubility

0.1 M NaOH: 13.7 mg/mL, DMSO: 14 mg/mL

SMILES string

OC(=O)c1cc(O)c2ccc(Cl)cc2n1

Gene Information

human ... GRIN1(2902)

Biochem/physiol Actions

Potent NMDA glutamate receptor antagonist; antagonizes the strychnine-insensitive glycine site of the NMDA receptor.
Potent NMDA glutamate receptor antagonist; antagonizes the strychnine-insensitive glycine site of the NMDA receptor; prevents neurodegeneration produced by quinolinic acid.

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