A9103

Anti-phospho-APP (pThr⁶⁶⁸) antibody produced in rabbit

affinity isolated antibody, aqueous glycerol solution, 10 blots

• UNSPSC Code: 12352203
• NACRES: NA.41
• MDL number: MFCD06798482
• Conjugate: unconjugated
• Clone: polyclonal
• Application: WB
• Citations: 6

Properties

• biological source: rabbit
• Quality Segment: 200
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: aqueous glycerol solution
• usage: 10 blots
• mol wt: antigen 100-140 kDa
• species reactivity: human
• technique(s): western blot: 1:1000 using CAD cells transfected with wild type vs. T668A mutant APP.
• UniProt accession no.: P05067
• storage temp.: −20°C
• Gene Information: human ... APP(351) ; mouse ... App(11820) ; rat ... App(54226)

Description

General description

Amyloid precursor proteins (APPs) are transmembrane glycoproteins that are found in a wide range of tissues. APPs have 3 main isoforms, namely, APP695, APP751 and APP770 that are derived from alternative splicing events in cells. Accumulation of the cleavage products of APP, such as the β-amyloid peptide, can cause Alzheimer′s disease.
Rabbit Anti-phospho-APP (pThr⁶⁶⁸⁾ antibody binds to human APP phosphorylated at Thr⁶⁶⁸. Mouse, rat and frog APP are 100% homologous.

Immunogen

synthetic phosphopeptide corresponding to the region of APP containing threonine 688.

Application

Cultured cortical neurons were immunostained for APP using rabbit anti-phospho-APP (pThr688) antibody.

Rabbit Anti-phospho-APP (pThr⁶⁶⁸) antibody can be used for western blot applications at a dilution of 1:1,000.

Physical form

Solution in Dulbecco′s phosphate buffered saline (without Mg²⁺ and Ca²⁺), pH 7.3, with 50% glycerol, 1.0 mg/mL BSA (IgG and protease free) and 0.05% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable