A7229
PUGNAc
≥95% (HPLC)
Synonym(s):
O-(2-Acetamido-2-deoxy-D-glucopyranosylidenamino) N-phenylcarbamate
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| Size/SKU | Availability | Price |
|---|---|---|
5 mg | Please contact Customer Service for Availability | PLN 866.00 |
10 mg | Please contact Customer Service for Availability | PLN 1,610.00 |
About This Item
Empirical Formula (Hill Notation):
C15H19N3O7
CAS Number:
Molecular Weight:
353.33
UNSPSC Code:
12352204
NACRES:
NA.26
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
4274031
Assay:
≥95% (HPLC)
Form:
crystals
PLN 866.00
Please contact Customer Service for Availability
Quality Segment
assay
≥95% (HPLC)
form
crystals
storage temp.
−20°C
SMILES string
CC(=O)N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O\C1=N/OC(=O)Nc2ccccc2
InChI
1S/C15H19N3O7/c1-8(20)16-11-13(22)12(21)10(7-19)24-14(11)18-25-15(23)17-9-5-3-2-4-6-9/h2-6,10-13,19,21-22H,7H2,1H3,(H,16,20)(H,17,23)/b18-14-/t10-,11-,12-,13-/m1/s1
InChI key
PBLNJFVQMUMOJY-JXZOILRNSA-N
Application
O-(2-acetamido-2deoxy-D-glucopyranosylidene)amino-N-phenylcarbamate (PUGNAc) has been used to evaluate the effects of silibinin on O-GlcNAc levels of glycoproteins in Adult Retinal Pigment Epithelial-19 (ARPE-19) cells. It has also been used as a component of the HEPES lysis buffer for rat brain samples.
PUGNAc has been used as an inhibitor of O-GlcNAc-β-N-acetylglucosaminidase.[1]
Biochem/physiol Actions
PUGNAc is an in vitro and in vivo inhibitor of peptide O-GlcNAc-β-N-acetylglucosaminidase, the enzyme which removes O-linked N-acetylglucosamine (O-GlcNAc) from O-linked glycosylated proteins.
O-(2-acetamido-2deoxy-D-glucopyranosylidene)amino-N-phenylcarbamate (PUGNAc) induces insulin resistance in 3T3-L1 adipocytes by reducing insulin-prompting phosphorylation of protein kinase B (Akt) and glycogen synthase kinase 3β (GSK3β).
1 of 1
This Item | |||
|---|---|---|---|
| assay ≥95% (HPLC) | assay ≥98% | assay ≥93% (HPLC) | assay ≥98% (TLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 200 | Quality Level 200 |
| form crystals | form powder | form powder | form powder |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. 2-8°C |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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