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Merck

A0232

Alfuzosin hydrochloride

≥98% (HPLC), solid

Synonym(s):

N-(3-((4-Amino-6,7-dimethoxy-2-quinazolinyl)methylamino)propyl)tetrahydro-2-furancarboxamide hydrochloride, Uroxatral hydrochloride

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5 MG

PLN 614.00

25 MG

PLN 2,330.00

PLN 614.00

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About This Item

Empirical Formula (Hill Notation):
C19H27N5O4 · HCl
CAS Number:
81403-68-1
Molecular Weight:
425.91
NACRES:
NA.77
PubChem Substance ID:
329770590
UNSPSC Code:
12352200
MDL number:
MFCD00879135
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
desiccated

Key Documents

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Quality Level

100

assay

≥98% (HPLC)

form

solid

storage condition

desiccated

solubility

DMSO: >10 mg/mL, H2O: insoluble

originator

Sanofi Aventis

SMILES string

Cl.COc1cc2nc(nc(N)c2cc1OC)N(C)CCCNC(=O)C3CCCO3

InChI

1S/C19H27N5O4.ClH/c1-24(8-5-7-21-18(25)14-6-4-9-28-14)19-22-13-11-16(27-3)15(26-2)10-12(13)17(20)23-19;/h10-11,14H,4-9H2,1-3H3,(H,21,25)(H2,20,22,23);1H

InChI key

YTNKWDJILNVLGX-UHFFFAOYSA-N

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)

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1 of 4

This Item
BP825A0325800BP847
Alfuzosin hydrochloride ≥98% (HPLC), solid

Sigma-Aldrich

A0232

Alfuzosin hydrochloride

Alfuzosin hydrochloride British Pharmacopoeia (BP) Reference Standard

BP825

Alfuzosin hydrochloride

Alfuzosin hydrochloride European Pharmacopoeia (EP) Reference Standard

A0325800

Alfuzosin hydrochloride

Alfuzosin impurity standard British Pharmacopoeia (BP) Reference Standard

BP847

Alfuzosin impurity standard

assay

≥98% (HPLC)

assay

-

assay

-

assay

-

form

solid

form

solid

form

-

form

solid

Quality Level

100

Quality Level

-

Quality Level

-

Quality Level

-

solubility

DMSO: >10 mg/mL, H2O: insoluble

solubility

-

solubility

-

solubility

-

storage condition

desiccated

storage condition

-

storage condition

-

storage condition

-

originator

Sanofi Aventis

originator

-

originator

-

originator

-

Biochem/physiol Actions

Alfuzosin hydrochloride is an alpha-adrenergic blocker used to treat benign prostatic hyperplasia (BPH). It works by relaxing the muscles in the prostate and bladder neck, making it easier to urinate.
Alfuzosin hydrochloride is an alpha-adrenergic blocker.

Features and Benefits

This compound is featured on the α1-Adrenoceptors and α2-Adrenoceptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000522707
0000522707
0000132367
0000132368
0000071598

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Jarosław Szulfer et al.
Journal of chromatography. A, 1346, 69-77 (2014-05-06)
This paper focuses on the application of a column classification system based on the Katholieke Universiteit Leuven for the characterization of physicochemical properties of core-shell and ultra-high performance liquid chromatographic stationary phases, followed by the verification of the reliability of
Satyanarayan Pattnaik et al.
Medicina (Kaunas, Lithuania), 51(4), 253-261 (2015-10-02)
There has been relatively little investigation of the effect of temperature on skin permeation compared to other methods of penetration enhancement. A principal physicochemical factor which controls the passive diffusion of a solute from a vehicle into the skin arises

Articles

α2-Adrenoceptory

Dowiedz się więcej o receptorze alfa-2 adrenergicznym i jego podtypach, pośredniczonych reakcjach i zastosowaniach agonistów. Zawiera listę dostępnych produktów i tabelę porównawczą.

α2-Adrenoceptors

Learn about alpha-2 adrenoceptor and its subtypes, mediated responses, and applications of agonists. Included is a list of available products and a comparison table.

α1-Adrenoceptor Characteristics and Modulators

Review alpha 1 adrenoceptors as well as their agonists, antagonists, and tissue expression patterns. We suggest several modulators and alternatives for working with a-1 adrenoreceptors.

Global Trade Item Number

SKUGTIN
A0232-5MG04061832071473
A0232-25MG04061832071466

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