449R-1

S100 beta (EP32) Rabbit Monoclonal Primary Antibody

• Synonym(s): S100 Calcium Binding Protein B
• UNSPSC Code: 12352203
• Conjugate: unconjugated
• Clone: EP32, monoclonal
• Application: IHC (p)
• Citations: 4

Properties

• biological source: rabbit
• Quality Segment: 100, 500
• conjugate: unconjugated
• antibody form: culture supernatant
• antibody product type: primary antibodies
• clone: EP32, monoclonal
• description: For In Vitro Diagnostic Use in Select Regions
• form: buffered aqueous solution
• species reactivity: human
• packaging: vial of 0.1 mL concentrate (449R-14), vial of 0.1 mL concentrate Research Use Only (449R-14-RUO), vial of 0.5 mL concentrate (449R-15), vial of 1.0 mL concentrate (449R-16), vial of 1.0 mL concentrate Research Use Only (449R-16-RUO), vial of 1.0 mL pre-dilute Research Use Only (449R-17-RUO), vial of 1.0 mL pre-dilute ready-to-use (449R-17), vial of 7.0 mL pre-dilute ready-to-use (449R-18), vial of 7.0 mL pre-dilute ready-to-use Research Use Only (449R-18-RUO)
• manufacturer/tradename: Cell Marque^®
• technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500 (concentrated)
• isotype: IgG
• control: melanoma
• shipped in: wet ice
• storage temp.: 2-8°C
• visualization: cytoplasmic

Description

General description

S100 calcium binding protein B (S100 beta) is a member of the multifunctional S100 family of proteins.[1][2][3] S100 beta acts as a stimulator of proliferation and migration and as an inhibitor of apoptosis and differentiation in many cell types including astrocytes, Schwann cells, chondrocytes, adipocytes, certain neuronal populations, melanocytes, Langerhans cells, histiocytes, epithelial, and myoepithelial cells.[1][2][3] S100 beta is also expressed in neoplasms derived from these cell types, making it a useful marker for the identification of melanoma and various nervous system tumors.[1][2][3] Although ubiquitous, S100 beta has proven to be a sensitive marker for malignant melanoma, including desmoplastic and metastatic variants.[4][1][2][3]

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

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Analysis Note

IVD

IVD

IVD

RUO

Other Notes

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Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable