445R-1

NKX2.2 (EP336) Rabbit Monoclonal Primary Antibody

• UNSPSC Code: 12352203
• Conjugate: unconjugated
• Clone: EP336, monoclonal
• Application: IHC (p)
• Citations: 5

Properties

• biological source: rabbit
• Quality Segment: 100, 500
• conjugate: unconjugated
• antibody form: culture supernatant
• antibody product type: primary antibodies
• clone: EP336, monoclonal
• description: For In Vitro Diagnostic Use in Select Regions
• form: buffered aqueous solution
• species reactivity: human
• packaging: vial of 0.1 mL concentrate (445R-14), vial of 0.1 mL concentrate Research Use Only (445R-14-RUO), vial of 0.5 mL concentrate (445R-15), vial of 1.0 mL concentrate (445R-16), vial of 1.0 mL concentrate Research Use Only (445R-16-RUO), vial of 1.0 mL pre-dilute Research Use Only (445R-17-RUO), vial of 1.0 mL pre-dilute ready-to-use (445R-17), vial of 7.0 mL pre-dilute ready-to-use (445R-18), vial of 7.0 mL pre-dilute ready-to-use Research Use Only (445R-18-RUO)
• manufacturer/tradename: Cell Marque^®
• technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500 (concentrated)
• isotype: IgG
• control: Ewing’s sarcoma, pancreas
• shipped in: wet ice
• storage temp.: 2-8°C
• visualization: nuclear

Description

General description

NKX2.2 is a homeodomain transcription factor that plays a role in neuroendocrine and glial differentiation.[1] NKX2.2 is upregulated in Ewing′s sarcoma as a result of the oncogenic EWS-FLI1 fusion protein.[2][3] As one of many small round blue cell tumors, Ewing′s sarcoma can be difficult to diagnose due to the characteristic undifferentiated morphology.[4] NKX2.2 has proven its utility as a sensitive maker for distinguishing Ewing′s sarcoma from other round blue cell tumors when used in a panel.[1][5]

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

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Analysis Note

IVD

IVD

IVD

RUO

Other Notes

For Technical Service please contact: 800-665-7284 or email: [email protected]

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable