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Merck

08486

5-Pyridoxolactone

≥98.5% (HPLC and enzymatic)

Synonym(s):

3-Carboxy-4-(hydroxymethyl)-5-hydroxy-6-methylpyridine lactone, 5-Pyridoxic acid γ-lactone, 7-Hydroxy-6-methylfuro[3,4-c]pyridin-3(1H)-one, NSC 15983, NSC 41813

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About This Item

Empirical Formula (Hill Notation):
C8H7NO3
CAS Number:
4543-56-0
Molecular Weight:
165.15
UNSPSC Code:
12352200
NACRES:
NA.79

Key Documents

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Product Name

5-Pyridoxolactone, ≥98.5% (HPLC and enzymatic)

InChI

1S/C8H7NO3/c1-4-7(10)6-3-12-8(11)5(6)2-9-4/h2,10H,3H2,1H3

InChI key

PPAXBSPBIWBREI-UHFFFAOYSA-N

assay

≥98.5% (HPLC and enzymatic)
98.5-101.5% (T)

form

powder

technique(s)

HPLC: suitable

color

white to light yellow

storage temp.

−20°C

Biochem/physiol Actions

5-Pyridoxolactone is a normal human metabolite of vitamin B6 metabolism.

General description

5-pyridoxolactone is a metabolite of vitamin B6.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
STBF3009V

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Identification of 5-pyridoxic acid and 5-pyridoxic acid lactone as metabolites of vitamin B6 in humans.
Mahuren, J. D., et al.
The Journal of Nutritional Biochemistry, 2, 449-453 (1991)
Determination of 5-pyridoxic acid, 5-pyridoxic acid lactone, and other vitamin B6 compounds by cation-exchange high-performance liquid chromatography.
J D Mahuren et al.
Methods in enzymology, 280, 22-29 (1997-01-01)
Vitamins (2013)
Y J Jong et al.
The Journal of biological chemistry, 261(32), 15112-15114 (1986-11-15)
4-Pyridoxolactone and 5-pyridoxolactone, formed by dehydrogenation of pyridoxal or isopyridoxal during the bacterial degradation of vitamin B6 by Pseudomonas MA-1 and Arthrobacter Cr-7, respectively, are hydrolyzed to the corresponding acids by distinct inducible lactonases which were purified to homogeneity. 4-Pyridoxolactonase
Junichi Funami et al.
Biochimica et biophysica acta, 1753(2), 234-239 (2005-10-18)
4-Pyridoxolactonase is involved in the degradation pathway for pyridoxine, a free form of vitamin B6. The gene (mlr6805) encoding the putative 4-pyridoxolactonase of nitrogen fixing symbiotic microorganism Mesorhizobium loti MAFF303099 has been identified based on the genome database. The gene
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