214906

Hypophosphorous acid solution

50 wt. % in H₂O

• Synonym(s): Phosphinic acid
• Linear Formula: H₃PO₂
• CAS Number: 6303-21-5
• Molecular Weight: 66.00
• MDL number: MFCD02183592
• UNSPSC Code: 12352106
• PubChem Substance ID: 329752159
• NACRES: NA.21

Properties

• vapor pressure: <17 mmHg ( 20 °C)
• Quality Level: 200
• form: liquid
• concentration: 48-52% in NaOH (titration); 50 wt. % in H₂O
• pH: 1 (20 °C, 500 g/L)
• density: 1.206 g/mL at 25 °C
• SMILES string: O[PH2]=O
• InChI: 1S/H3O2P/c1-3-2/h3H2,(H,1,2)
• InChI key: ACVYVLVWPXVTIT-UHFFFAOYSA-N

Description

General description

H₃PO_2, a monobasic oxyacid, is also referred to as phosphinic acid. H₃PO₂ participates as a reducing agent for the conversion of aromatic and aliphatic diselenides to the corresponding selenols.
It undergoes oxidation in the presence of Ce(IV) and a strong acid to afford cerium(IV) hypophosphite complex ions.

Application

• Synthesis of Aminobisphosphinates through a Cascade Reaction between Hypophosphorous Acid and Bis(trimethylsilyl)imidates Mediated by ZnI(2).: This research presents a novel method for synthesizing aminobisphosphinates, utilizing hypophosphorous acid in a zinc iodide-mediated cascade reaction, which could be relevant in the development of new chemical entities in medicinal chemistry (Ayadi et al., 2023).


• Facile Synthesis of Liquid Crystal Dimers Bridged with a Phosphonic Group.: This study explores the use of hypophosphorous acid in the synthesis of phosphonic group-bridged liquid crystal dimers, offering potential advancements in materials science and display technologies (Wang et al., 2022).


• Oxidation of Hypophosphorous Acid by a Ruthenium(VI) Nitrido Complex in Aqueous Acidic Solution. Evidence for a Proton-Coupled N-Atom Transfer Mechanism.: Investigates the mechanistic details of hypophosphorous acid oxidation by a ruthenium complex, shedding light on reaction pathways important in catalysis and synthesis (Li et al., 2022).


• Solution-processed Ge(ii)-based chalcogenide thin films with tunable bandgaps for photovoltaics.: Discusses the application of hypophosphorous acid in the development of germanium-based chalcogenide thin films, contributing to advancements in photovoltaic materials (Hu et al., 2022).


• One-Pot Synthesis and in Silico Molecular Docking Studies of Arylselanyl Hydrazides as Potential Antituberculosis Agents.: Utilizes hypophosphorous acid in the one-pot synthesis of arylselanyl hydrazides, evaluated for their potential as antituberculosis agents through molecular docking studies (Borges et al., 2022).

Safety Information

• Pictograms: GHS05
• Signal Word: Danger
• Hazard Statements: H290,H314
• Precautionary Statements: P234 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363
• Hazard Classifications: Eye Dam. 1 - Met. Corr. 1 - Skin Corr. 1B
• Storage Class Code: 8B - Non-combustible corrosive hazardous materials
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable