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21980
Cardiogreen
suitable for microscopy
Synonym(s):
Foxgreen, IC Green, Indocyanine green
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| Size/SKU | Availability | Price |
|---|---|---|
100 mg | Please contact Customer Service for Availability | PLN 1,300.00 |
500 mg | Please contact Customer Service for Availability | PLN 5,170.00 |
About This Item
Empirical Formula (Hill Notation):
C43H47N2NaO6S2
CAS Number:
Molecular Weight:
774.96
UNSPSC Code:
12171500
NACRES:
MA.02
PubChem Substance ID:
EC Number:
222-751-5
Beilstein/REAXYS Number:
4115884
MDL number:
form
powder
Quality Segment
technique(s)
titration: suitable
color
green to very dark green
solubility
water: 0.01 g/10 mL
ε (extinction coefficient)
≥115 at 386-396 nm in water, ≥2000 at 774-784 nm in water, ≥900 at 712-722 nm in water
suitability
suitable for microscopy
application(s)
diagnostic assay manufacturing
hematology
histology
storage temp.
room temp
SMILES string
[Na+].CC1(C)/C(=C\C=C\C=C\C=C\C2=[N+](CCCCS([O-])(=O)=O)c3ccc4ccccc4c3C2(C)C)N(CCCCS([O-])(=O)=O)c5ccc6ccccc6c15
InChI
1S/C43H48N2O6S2.Na/c1-42(2)38(44(28-14-16-30-52(46,47)48)36-26-24-32-18-10-12-20-34(32)40(36)42)22-8-6-5-7-9-23-39-43(3,4)41-35-21-13-11-19-33(35)25-27-37(41)45(39)29-15-17-31-53(49,50)51;/h5-13,18-27H,14-17,28-31H2,1-4H3,(H-,46,47,48,49,50,51);/q;+1/p-1
InChI key
MOFVSTNWEDAEEK-UHFFFAOYSA-M
General description
Cardiogreen is a dye used for microscopy. This dye has its maximum extinction at the same wavelength as reduced and oxygenated haemoglobin meet making it possible to record the oxygen saturation in blood. This dye has no side-effects.[1]
Application
Cardiogreen was injected in animals intravenously for dynamic optical imaging system to study the capability of capturing the in vivo biodistribution kinetics.[2]
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Other Notes
A diagnostic aid in the determination of hepatic function
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This Item | |||
|---|---|---|---|
| suitability suitable for microscopy | suitability - | suitability - | suitability - |
| technique(s) titration: suitable | technique(s) - | technique(s) titration: suitable | technique(s) - |
| color green to very dark green | color - | color green to very dark green | color blue-green |
| solubility water: 0.01 g/10 mL | solubility - | solubility water: 0.01 g/mL | solubility H2O: 1 mg/mL |
| form powder | form - | form powder | form powder |
| application(s) diagnostic assay manufacturing | application(s) pharmaceutical (small molecule) | application(s) diagnostic assay manufacturing | application(s) diagnostic assay manufacturing |
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signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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What is the Department of Transportation shipping information for this product?
1 answer-
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Can Product No. I2633, Cardiogreen, be used as a biological stain?
1 answer-
Limited absorbance in the visible region practically precludes the use of Indocyanine Green as a biological stain. See: Sigma-Aldrich Handbook of Dyes, Stains, and Indicators, Green, F. ed., p. 407.
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Does Cardiogreen dissolve equally well in saline and in water?
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Each lot is tested for solubility in hot water at 1 mg/mL. We have found that Sigma Product No. I2633 (which has the same CAS number as Product No. 21980) dissolves in water at 1 mg/mL without heating. Further dilute in saline to prepare an isotonic solution.
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Has Cardiogreen been used for in vivo optical imaging studies?
1 answer-
We do not subject this product to in vivo testing. However, one study documents the use of the product in a study with mice:For optical imaging, mice were injected intravenously with a mixture of 0.05 ml of 260 μM ICG (Cardiogreen) and 0.05 ml of 360 μM DTR (70,000 MW, Invitrogen) in saline (equivalent to 0.4 mg per kg or 7.4 μM initial concentration in blood).
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How long can I store a solution of Cardiogreen after it has been prepared?
1 answer-
Sigma-Aldrich recommends that solutions be prepared fresh and not stored. Solutions "are stable only for a few hours and cannot be kept overnight." See: Sigma-Aldrich Handbook of Dyes, Stains, and Indicators, Green, F. ed., p. 407.
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How does the storage temperature relate to shipping conditions?
1 answer-
The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.
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