8.53078

Boc-Trp(Boc)-OH

Novabiochem^®

• Synonym(s): Boc-Trp(Boc)-OH, N-α-t.-Boc-N-in-t.-Boc-L-trypophan
• Empirical Formula (Hill Notation): C₂₁H₂₈N₂O₆
• CAS Number: 144599-95-1
• Molecular Weight: 404.46
• MDL number: MFCD00270520
• UNSPSC Code: 12352209
• NACRES: NA.22

Properties

• Quality Segment: 200
• product line: Novabiochem^®
• assay: ≥98% (TLC)
• form: powder
• reaction suitability: reaction type: Boc solid-phase peptide synthesis
• manufacturer/tradename: Novabiochem^®
• application(s): peptide synthesis
• storage temp.: 15-25°C
• SMILES string: [n]1(c2c(c(c1)C[C@H](NC(=O)OC(C)(C)C)C(=O)O)cccc2)C(=O)OC(C)(C)C
• InChI: 1S/C21H28N2O6/c1-20(2,3)28-18(26)22-15(17(24)25)11-13-12-23(19(27)29-21(4,5)6)16-10-8-7-9-14(13)16/h7-10,12,15H,11H2,1-6H3,(H,22,26)(H,24,25)/t15-/m0/s1
• InChI key: FATGZMFSCKUQGO-HNNXBMFYSA-N

Description

General description

N-in-Boc protection limits reattachment and leads to higher cleavage yields of C-terminal Trp-containing peptides.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Boc SPPS

Analysis Note

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Optical rotation α 25/D (c=1 in methanol): +13.5 - +17.5 °
Purity (TLC(011A)): ≥ 98 %
Purity (TLC(0811)): ≥ 98 %
Solubility (1 mmole in 2 ml DMF): clear solution

To see the solvent systems used for TLC of Novabiochem^® products please click here.

Other Notes

Replaces: 04-12-0205

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable