8.00592

Phthalic anhydride

for synthesis

• Synonym(s): Phthalic anhydride
• Empirical Formula (Hill Notation): C₈H₄O₃
• CAS Number: 85-44-9
• Molecular Weight: 148.12
• UNSPSC Code: 12352115
• EC Index Number: 201-607-5
• NACRES: NA.22
• MDL number: MFCD00005918
• Form: crystals

Properties

• vapor pressure: <0.01 hPa ( 20 °C)
• Quality Segment: 200
• form: crystals
• autoignition temp.: 580 °C
• potency: 1530 mg/kg LD₅₀, oral (Rat), >3160 mg/kg LD₅₀, skin (Rabbit)
• expl. lim.: 1.7-10.5 % (v/v)
• pH: 2 (20 °C, 6 g/L in H₂O)
• bp: 285 °C/1013 hPa
• mp: 131 °C
• transition temp: flash point 152 °C
• solubility: 6 g/L (slow decomposition)
• density: 1.527 g/cm³ at 20 °C
• bulk density: 500‑700 kg/m³
• storage temp.: no temp limit
• SMILES string: O1C(=O)c2c(cccc2)C1=O
• InChI: 1S/C8H4O3/c9-7-5-3-1-2-4-6(5)8(10)11-7/h1-4H
• InChI key: LGRFSURHDFAFJT-UHFFFAOYSA-N

Description

Application

<ul>
<li><strong>Antibacterial and cytotoxic activity of chitosan derivatives:</strong>Phthalic anhydride-modified chitosan derivatives exhibit significant antibacterial and cytotoxic properties, suggesting their potential application in medical and pharmaceutical products (Sousa et al., 2024).</li>
<li><strong>Heterodinuclear Polymerization Catalysts:</strong> Research identified Al(III)/K(I) polymerization catalysts that utilize phthalic anhydride for producing high-quality polyester polyols, offering advancements in polymer synthesis technology (Shellard et al., 2024).</li>
<li><strong>Advanced epoxy vitrimers:</strong> Phthalic anhydride was used in the design and synthesis of advanced epoxy vitrimers with enhanced glass transition temperatures, important for applications requiring high-performance thermoset polymers (Dai et al., 2023).</li>
<li><strong>Sustainable alkyd resins:</strong> The utilization of phthalic anhydride in the production of alkyd resins from bio-based resources represents a significant move towards more sustainable and environmentally friendly coating applications (Dizman and Cerrahoglu Ka and ccedil;akgil, 2023).</li>
</ul>

Analysis Note

Assay (morpholine method): ≥ 98,0 %(m)
Melting range (lower value): ≥ 129 °C
Melting range (upper value): ≤ 133 °C
Identity (IR): conforms

Safety Information

• pictograms: GHS08,GHS05,GHS07
• signalword: Danger
• hcodes: H302,H315,H317,H318,H334,H335
• pcodes: P261 - P280 - P301 + P312 - P302 + P352 - P304 + P340 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Dam. 1 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 8A - Combustible corrosive hazardous materials
• wgk: WGK 1
• flash_point_f: 305.6 °F - DIN 51758
• flash_point_c: 152 °C - DIN 51758