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658452

AG 126

A cell-permeable inhibitor of lipopolysaccharide (LPS)-induced synthesis of tumor necrosis factor-α and nitric oxide in murine peritoneal macrophages.

Synonym(s):

AG 126, α-Cyano-(3-hydroxy-4-nitro)cinnamonitrile

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Size/SKUAvailabilityPrice
5 mg

Estimated to ship onJuly 09, 2026fromKuehne + Nagel Sp. z o.o.

PLN 753.00

About This Item

Empirical Formula (Hill Notation):
C10H5N3O3
CAS Number:
118409-62-4
Molecular Weight:
215.17
MDL number:
MFCD00236448
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light

PLN 753.00

Estimated to ship onJuly 09, 2026Details

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Quality Segment

100

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

yellow

solubility

DMSO: 5 mg/mL, DMF: soluble

shipped in

ambient

storage temp.

−20°C

SMILES string

[N+](=O)([O-])c1c(cc(cc1)C=C(C#N)C#N)O

InChI

1S/C10H5N3O3/c11-5-8(6-12)3-7-1-2-9(13(15)16)10(14)4-7/h1-4,14H

InChI key

DUQADSPERJRQBW-UHFFFAOYSA-N

General description

A cell-permeable inhibitor of lipopolysaccharide (LPS)-induced synthesis of tumor necrosis factor-α and nitric oxide in murine peritoneal macrophages. Blocks LPS-induced tyrosine phosphorylation of a p42MAPK/ERK2 protein substrate. Reduces the expression of iNOS and COX-2 in lungs of rats treated with carrageenan. Blocks glucocorticoid-induced COX-2 activity in human amnion cells (IC50 = 15.38 µM).

Biochem/physiol Actions

Cell permeable: yes
Primary Target
COX-2 activity
Product does not compete with ATP.
Reversible: no
Target IC50: 15.38 µM in blocking glucocorticoid-induced COX-2 activity in human amnion cells

Other Notes

Cuzzocrea, S., et al. 2000. Am. J. Pathol.157, 145.
Zakar, T., et al. 1999. Can. J. Physiol. Pharmacol.77, 138.
Kan, H., et al. 1996. Mol. Pharmacol.50, 1139.
Novogrodsky, A., et al. 1994. Science264, 1319.
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Toxic (F)

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AG 126 A cell-permeable inhibitor of lipopolysaccharide (LPS)-induced synthesis of tumor necrosis factor-α and nitric oxide in murine peritoneal macrophages.

Sigma-Aldrich

658452

AG 126

AG 18 A broad-spectrum protein tyrosine kinase inhibitor.

Sigma-Aldrich

658395

AG 18

AG 825 A potent, cell-premeable, reversible, substrate competitive, and selective inhibitor of HER2 (neu/ErbB2; IC50 = 0.35 µM) relative to HER1 (IC50= 19 µM) autophosphorylation.

Sigma-Aldrich

121765

AG 825

AG 1024 A cell-permeable, reversible, substrate competitive, and specific inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor tyrosine kinase activity.

Sigma-Aldrich

121767

AG 1024

assay

≥95% (HPLC)

assay

≥98% (HPLC)

assay

≥94% (HPLC)

assay

≥98% (HPLC)

form

solid

form

solid

form

solid

form

solid

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

solubility

DMSO: 5 mg/mL, DMF: soluble

solubility

DMSO: 100 mg/mL, ethanol: 50 mg/mL, acetic acid: soluble

solubility

DMSO: 10 mg/mL

solubility

DMSO: 10 mg/mL

Storage Class

11 - Combustible Solids

wgk

WGK 3

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