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648494

TRPC3 Channel Inhibitor III, Pyr10

Synonym(s):

TRPC3 Channel Inhibitor III, Pyr10, N-(4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)-4-methylbenzenesulfonamide

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Size/SKUAvailabilityPrice
10 mg

Estimated to ship onJune 03, 2026fromKuehne + Nagel Sp. z o.o.

PLN 935.00

About This Item

Empirical Formula (Hill Notation):
C18H13F6N3O2S
CAS Number:
1315323-00-2
Molecular Weight:
449.37
MDL number:
MFCD28411625
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
semisolid, solid
Storage condition:
OK to freeze, protect from light

PLN 935.00

Estimated to ship onJune 03, 2026Details

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assay

≥98% (HPLC)

Quality Segment

100

form

semisolid, solid

potency

720 nM IC50

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

orange-brown, white to off-white

solubility

DMSO: 100 mg/mL

shipped in

wet ice

storage temp.

2-8°C

SMILES string

FC(F)(F)c1[n](nc(c1)C(F)(F)F)c2ccc(cc2)N[S](=O)(=O)c3ccc(cc3)C

InChI

1S/C18H13F6N3O2S/c1-11-2-8-14(9-3-11)30(28,29)26-12-4-6-13(7-5-12)27-16(18(22,23)24)10-15(25-27)17(19,20)21/h2-10,26H,1H3

InChI key

CVALMMCIOLXHDM-UHFFFAOYSA-N

General description

A cell-permeable pyrazole derivative that acts as a selective blocker of the transient receptor potential cation channel TRPC3-medated ROCE (receptor-operated Ca2+ entry) and inhibits Carbachol- (Cat. No. 212385) induced Ca2+ entry in TRPC3-expressing HEK293 cells (IC50 = 0.72 µM; by Fura-2), while exhibiting much reduced potency against Stim1 and Orai1-coupled CRAC (Ca2+ release-activated Ca2+) channel-mediated SOCE (store-operated Ca2+ entry) in RBL-2H3 cells (IC50 = 13.08 µM; by Fura-2). A great complement to Pyr2 (Cat. No. 203890), Pyr 3 (Cat. No. 648490), and Pyr6 (Cat. No. 203891) in Ca2+ signaling studies.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
TRPC3
Reversible: yes

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Schleifer, H. et al. 2012. Br. J. Pharmacol.167, 1712.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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TRPC3 Channel Inhibitor III, Pyr10

Sigma-Aldrich

648494

TRPC3 Channel Inhibitor III, Pyr10

TRPC3 Channel Inhibitor, Pyr3 The TRPC3 Channel Inhibitor, Pyr3, also referenced under CAS 1160514-60-2, controls the biological activity of TRPC3 Channel. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Sigma-Aldrich

648490

TRPC3 Channel Inhibitor, Pyr3

MK-2 Inhibitor III The MK-2 Inhibitor III, also referenced under CAS 1186648-22-5, controls the biological activity of MK-2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sigma-Aldrich

475864

MK-2 Inhibitor III

JNK3 Inhibitor XII, SR-3576 The JNK3 Inhibitor XII, SR-3576, also referenced under CAS 1164153-22-3, controls the biological activity of JNK3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sigma-Aldrich

420143

JNK3 Inhibitor XII, SR-3576

assay

≥98% (HPLC)

assay

≥95% (HPLC)

assay

≥97% (HPLC)

assay

≥95% (HPLC)

form

semisolid

form

solid

form

solid

form

solid

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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