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567735

Sphingosylphosphoryl-choline

SPC is the deacylated derivative of sphingomyelin known to accumulate in neuropathic Niemann-Pick disease type A.

Synonym(s):

Sphingosylphosphoryl-choline, SPC, lyso-Sphingomyelin

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Size/SKUAvailabilityPrice
10 mg

Estimated to ship onJune 10, 2026fromKuehne + Nagel Sp. z o.o.

PLN 1,630.00

About This Item

Empirical Formula (Hill Notation):
C23H49N2O5P
CAS Number:
1670-26-4
Molecular Weight:
464.62
UNSPSC Code:
12352211
NACRES:
NA.77
MDL number:
MFCD02259287
Assay:
≥98% (TLC)
Form:
solid
Storage condition:
OK to freeze, desiccated

PLN 1,630.00

Estimated to ship onJune 10, 2026Details

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Quality Segment

100

assay

≥98% (TLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated

color

white

solubility

chloroform/methanol (2:1): 1 mg/mL

shipped in

ambient

storage temp.

−20°C

SMILES string

[P](=O)([O-])(OC[C@H](N)[C@H](O)\C=C\CCCCCCCCCCCCC)OCC[N+](C)(C)C

InChI

1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m0/s1

InChI key

JLVSPVFPBBFMBE-HXSWCURESA-N

General description

SPC is the deacylated derivative of sphingomyelin known to accumulate in neuropathic Niemann-Pick disease type A. A potent mitogen that increases intracellular free Ca2+ and free arachidonate through pathways that are only partially PKC-dependent. Stimulates DNA-binding activity of the transcription activator protein AP-1. Rapidly induces tyrosine phosphorylation of focal adhesion kinase (p125FAK) and paxillin and causes a rapid and transient activation of MAP kinase in Swiss/3T3 cells. Also induces a unique reorganization of the actin cytoskeleton.

Biochem/physiol Actions

Cell permeable: no
Primary Target
A potent mitogen
Product does not compete with ATP.
Reversible: no

Preparation Note

Following initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.

Other Notes

Berger, A., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 5885.
Dettbarn, C., et al. 1995. Brain Res.669, 79.
Seufferlein, T. and Rozengurt, E. 1995. J. Biol. Chem. 270, 24343.
Seufferlein, T. and Rozengurt, E. 1995. J. Biol. Chem. 270, 24334.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Sphingosylphosphoryl-choline SPC is the deacylated derivative of sphingomyelin known to accumulate in neuropathic Niemann-Pick disease type A.

Sigma-Aldrich

567735

Sphingosylphosphoryl-choline

D-erythro-Sphingosine, N-Acetyl- Biologically active, cell-permeable, non-physiological ceramide analog.

Sigma-Aldrich

110145

D-erythro-Sphingosine, N-Acetyl-

D-erythro-Sphingosine, Free Base, High Purity Highly purified preparation of bovine brain sphingosine containing >99% of the erythro isomer.

Sigma-Aldrich

567726

D-erythro-Sphingosine, Free Base, High Purity

Sphingosine Kinase Inhibitor The Sphingosine Kinase Inhibitor, also referenced under CAS 1177741-83-1, controls the biological activity of Sphingosine Kinase. This small molecule/inhibitor is primarily used for Cell Signaling applications.

Sigma-Aldrich

567731

Sphingosine Kinase Inhibitor

form

solid

form

solid

form

solid

form

solid

assay

≥98% (TLC)

assay

≥98% (TLC)

assay

≥98% (TLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

solubility

chloroform/methanol (2:1): 1 mg/mL

solubility

DMSO: 25 mg/mL, ethanol: 5 mg/mL, methanol: 5 mg/mL

solubility

chloroform: 1 mg/mL, methanol: 1 mg/mL, DMSO: 10 mg/mL

solubility

DMSO: 5 mg/mL

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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