539142

Proteasome Substrate III, Fluorogenic

≥98% (HPLC), amorphous solid, proteasome substrate, Calbiochem^®

• Synonym(s): Proteasome Substrate III, Fluorogenic, Suc-LLVY-AMC, Chymotrypsin Substrate III, Fluorogenic
• Empirical Formula (Hill Notation): C₄₀H₅₃N₅O₁₀
• Molecular Weight: 763.88
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: amorphous solid
• Storage condition: OK to freeze, protect from light

Properties

• Product Name: Proteasome Substrate III, Fluorogenic, Proteasome Substrate III, Fluorogenic, is a substrate for proteasome. Also acts as a substrate for calpain, chymotrypsin, and ingensin.
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: amorphous solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: white
• solubility: DMSO: 50 mg/mL
• fluorescence: λ_ex ~380 nm, λ_em ~460 nm
• shipped in: ambient
• storage temp.: −20°C

Description

General description

Fluorogenic proteasome substrate. Also acts as a substrate for calpain, chymotrypsin, and ingensin.

Biochem/physiol Actions

Cell permeable: no

Inhibits serine proteases and cysteine proteases.

Primary Target
Proteasome

Product does not compete with ATP.

Reversible: no

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Anderson, M., et al. 1999. Exp. Eye Res.69, 129.
Rock, K.L., et al. 1994. Cell 78, 761.
Tsubuki, S., et al. 1993. Biochem. Biophys. Res. Commun.196, 1195.
Sasaki, T., et al. 1984. J. Biol. Chem. 259, 12489.

Suc-Leu-Leu-Val-Tyr-AMC

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable