513100

DL-threo-PDMP, Hydrochloride

PDMP closely resembles the natural sphingolipid substrate of brain glucosyltransferase and acts as a potent and competitive inhibitor of this enzyme.

• Synonym(s): DL-threo-PDMP, Hydrochloride, 1-Phenyl-2-decanoylamino-3-morpholino-1-propanol, HCl
• Empirical Formula (Hill Notation): C₂₃H₃₈N₂O₃ · xHCl
• CAS Number: 80938-69-8
• Molecular Weight: 390.56 (free base basis)
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00236490
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: OK to freeze

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: white
• solubility: DMSO: soluble, ethanol: soluble, methanol: soluble
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: Cl.N2(CCOCC2)C[C@@H](NC(=O)CCCCCCCCC)[C@H](O)c1ccccc1
• InChI: 1S/C23H38N2O3.ClH/c1-2-3-4-5-6-7-11-14-22(26)24-21(19-25-15-17-28-18-16-25)23(27)20-12-9-8-10-13-20;/h8-10,12-13,21,23,27H,2-7,11,14-19H2,1H3,(H,24,26);1H/t21-,23-;/m1./s1
• InChI key: HVJHJOYQTSEKPK-BLDCTAJRSA-N

Description

General description

PDMP closely resembles the natural sphingolipid substrate of brain glucosyltransferase and acts as a potent and competitive inhibitor of this enzyme. Blocks the outgrowth of neurites and inhibits glycolipid synthesis in cultured NIH/3T3 cells.

Biochem/physiol Actions

Cell permeable: no

Primary Target
glycolipid synthesis in cultured NIH/3T3 cells

Product does not compete with ATP.

Reversible: no

Other Notes

Rani, C.S., et al. 1995. J. Biol. Chem. 270, 2859.
Rosenwald, A.G. 1992. Biochemistry31, 3581.
Inokuchi, J., and Radin, N.S. 1987. J. Lipid Res.28, 565.
Vunnam, R.R., and Radin, N.S. 1980. Chem. Phys. Lipids26, 265.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable