5.05051

2,3 cis-Piperidine dicarboxylic acid

• Synonym(s): 2,3 cis-Piperidine dicarboxylic acid, Ionotropic Glutamate Receptor Antagonist, PDA, cis PDA, cis-Piperidine-2,3-dicarboxylic acid
• Empirical Formula (Hill Notation): C₇H₁₁NO₄
• CAS Number: 46026-75-9
• Molecular Weight: 173.17
• UNSPSC Code: 12352106
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• Quality Level: 100
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: white
• solubility: water: 100 mM
• storage temp.: 2-8°C
• InChI: 1S/C7H11NO4/c9-6(10)4-2-1-3-8-5(4)7(11)12/h4-5,8H,1-3H2,(H,9,10)(H,11,12)
• InChI key: PTLWNCBCBZZBJI-UHFFFAOYSA-N

Description

General description

A non-specific antagonist of NMDA, AMPA and kainate ionotropic receptors and a partial agonist for NMDA receptors. Used in blocking general excitatory synaptic transmissions.

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Tong, G., et al. 1994. Neuron13, 1195.
Leach, J., et al. 1986. Eur. J. Pharmacol.121, 173.
Watkins, C., et al. 1981. Annu. Rev. Pharmacol. Toxicol.21, 165.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable