487950

NOC-5

A nitric oxide (NO) donor.

• Synonym(s): NOC-5, 3-[2-Hydroxy-1-(1-methylethyl)-2-nitrosohydrazino]-1-propanamine
• Empirical Formula (Hill Notation): C₆H₁₆N₄O₂
• CAS Number: 146724-82-5
• Molecular Weight: 176.22
• UNSPSC Code: 12352200
• MDL number: MFCD00274389
• Assay: ≥95% (HPLC)
• Form: solid
• Storage condition: OK to freeze, desiccated (hygroscopic), protect from light

Properties

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated (hygroscopic), protect from light
• color: white
• solubility: 0.1 M NaOH: soluble, water: soluble
• shipped in: ambient
• storage temp.: −20°C
• InChI: 1S/C6H16N4O2/c1-6(2)9(5-3-4-7)10(12)8-11/h6,12H,3-5,7H2,1-2H3
• InChI key: WEHZRCACNLQADC-UHFFFAOYSA-N

Description

General description

A nitric oxide (NO) donor. A stable NO-amine complex that can spontaneously release two equivalents of NO in solution under physiological conditions without any cofactor. Half-life (t_½) in PBS, pH 7.4 is 93 minutes at 22°C. Relatively stable in alkaline solution (pH ≥10.0).

Biochem/physiol Actions

Cell permeable: no

Primary Target
A nitric oxide (NO) donor

Product does not compete with ATP.

Reversible: no

Preparation Note

Following reconstitution in alkaline solution, aliquot and freeze (-20°C). Unstable in aqueous solutions; reconstitute in H₂O just prior to use. Alkaline stock solutions are stable for up to 3 months at -20°C.

Other Notes

Hrabie, J.A., et al. 1993. J. Org. Chem. 58, 1472.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

Safety Information

• pictograms: GHS02
• signalword: Danger
• hcodes: H242
• pcodes: P210 - P234 - P235 - P240 - P370 + P378 - P403
• Hazard Classifications: Self-react. C
• Storage Class: 5.2 - Organic peroxides and self-reacting hazardous materials
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable