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480747

Neurogenesis Inducer V, KHS101

A blood brain barrier permeable pyrimidinyl-aminothiazole compound that specifically interacts with TACC3 (transforming acidic coiledcoil-containing protein 3) and promotes nuclear localization of ARNT2 (aryl-hydrocarbon receptor nuclear translocator 2).

Synonym(s):

Neurogenesis Inducer V, KHS101, N⁴-Isobutyl-N²-((2-phenylthiazol-4-yl)methyl)pyrimidine-2,4-diamine

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Size/SKUAvailabilityPrice
10 mg

Estimated to ship TODAYfromKuehne + Nagel Sp. z o.o.

PLN 553.00

About This Item

Empirical Formula (Hill Notation):
C18H21N5S
CAS Number:
1262770-73-9
Molecular Weight:
339.46
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD18206916
Assay:
≥95% (HPLC)
Form:
resin (Sticky)
Storage condition:
OK to freeze, protect from light

PLN 553.00

Estimated to ship TODAYDetails

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Quality Segment

100

assay

≥95% (HPLC)

form

resin (Sticky)

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

yellow

solubility

DMSO: 100 mg/mL

shipped in

wet ice

storage temp.

2-8°C

SMILES string

[s]1c(nc(c1)CNc3nc(ccn3)NCC(C)C)c2ccccc2

InChI

1S/C18H21N5S/c1-13(2)10-20-16-8-9-19-18(23-16)21-11-15-12-24-17(22-15)14-6-4-3-5-7-14/h3-9,12-13H,10-11H2,1-2H3,(H2,19,20,21,23)

InChI key

DGRJOOOHPBSAHD-UHFFFAOYSA-N

General description

A blood brain barrier permeable pyrimidinyl-aminothiazole compound that specifically interacts with TACC3 (transforming acidic coiledcoil-containing protein 3) and promotes nuclear localization of ARNT2 (aryl-hydrocarbon receptor nuclear translocator 2). Shown to significantly induce neuronal differentiation of cultured rat hippocampal NPCs (neural progenitor cells; EC50 ~ 1 µM) and in adult rats (6 mg/kg, s.c.) and suppress proliferation.

Packaging

Packaged under inert gas

Other Notes

Wurdak, H., et al. 2010. Proc. Natl. Acad. Sci. USA107, 16542

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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480743361554420129
Neurogenesis Inducer V, KHS101 A blood brain barrier permeable pyrimidinyl-aminothiazole compound that specifically interacts with TACC3 (transforming acidic coiledcoil-containing protein 3) and promotes nuclear localization of ARNT2 (aryl-hydrocarbon receptor nuclear translocator 2).

Sigma-Aldrich

480747

Neurogenesis Inducer V, KHS101

Neuronal Differentiation Inducer III A cell-permeable isoxazole compound that selectively induces robust neuronal differentiation (Effective concentration = 20 µM) in various stem/progenitor cells.

Sigma-Aldrich

480743

Neuronal Differentiation Inducer III

GSK-3β Inhibitor XII, TWS119 The GSK-3β Inhibitor XII, TWS119, also referenced under CAS 601514-19-6, controls the biological activity of GSK-3β. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sigma-Aldrich

361554

GSK-3β Inhibitor XII, TWS119

JNK Inhibitor V The JNK Inhibitor V, also referenced under CAS 345987-15-7, controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sigma-Aldrich

420129

JNK Inhibitor V

form

resin (Sticky)

form

solid

form

solid

form

solid

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (sum of two isomers, HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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