33-055
PIP4-Kinase HTRF Assay
The PIP4 Kinase HTRF Assay kit provides a method for assaying PI(5)P-4 kinases in a homogenous 1920 well format. Suitable for screening of potential inhibitors of these enzymes.
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About This Item
UNSPSC Code:
12161503
eCl@ss:
32161000
species reactivity
human, mouse
manufacturer/tradename
HTRF®
Upstate®
technique(s)
activity assay: suitable (kinase)
NCBI accession no.
detection method
fluorometric (HTRF)
shipped in
dry ice
Application
Research Category
Apoptosis & Cancer
Apoptosis & Cancer
Research Sub Category
Oncology
Oncology
The PIP4 Kinase HTRF Assay kit provides a method for assaying PI(5)P-4 kinases in a homogenous 1920 well format. Suitable for screening of potential inhibitors of these enzymes.
Used to detect/quantify: PIP4 Kinase
Biochem/physiol Actions
Target Sub-Family: PI3K/PI4K
Packaging
Kit capacity: 1920 wells
Components
Reaction Buffer (4X)
DM A Detection Reagent
DM C Detection Reagent
DM E Detection Reagent
Phosphatidylinositol 5-phosphate (1mM)
Phosphatidylserine (1mM)
Stop Reagent D
DM A Detection Reagent
DM C Detection Reagent
DM E Detection Reagent
Phosphatidylinositol 5-phosphate (1mM)
Phosphatidylserine (1mM)
Stop Reagent D
Storage and Stability
12 months at -70°C
Legal Information
HTRF is a registered trademark of Cis Bio International
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage Class Code
10-13 - German Storage Class 10 to 13
Certificates of Analysis (COA)
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Lars Wortmann et al.
Journal of medicinal chemistry, 64(21), 15883-15911 (2021-10-27)
PIP4K2A is an insufficiently studied type II lipid kinase that catalyzes the conversion of phosphatidylinositol-5-phosphate (PI5P) into phosphatidylinositol 4,5-bisphosphate (PI4,5P2). The involvement of PIP4K2A/B in cancer has been suggested, particularly in the context of p53 mutant/null tumors. PIP4K2A/B depletion has
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