234599

Conduritol B Epoxide

≥98% (HPLC), solid, Glucocerebrosidase inhibitor, Calbiochem^®

• Synonym(s): Conduritol B Epoxide, CBE, 1,2-Anhydro-myo-inositol
• Empirical Formula (Hill Notation): C₆H₁₀O₅
• CAS Number: 6090-95-5
• Molecular Weight: 162.14
• MDL number: MFCD27918490
• UNSPSC Code: 12352119
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: OK to freeze, desiccated

Properties

• Product Name: Conduritol B Epoxide, Conduritol B Epoxide, CAS 6090-95-5, is an irreversible Inhibitor of glucocerebrosidase in neurons. Also inhibits α-glucosidase activity in a variety of species.
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated
• color: white
• solubility: DMSO: soluble, water: soluble
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: O1[C@@H]2[C@H]1[C@@H]([C@H]([C@@H]([C@H]2O)O)O)O
• InChI: 1S/C6H10O5/c7-1-2(8)4(10)6-5(11-6)3(1)9/h1-10H/t1-,2-,3+,4+,5-,6+/m0/s1
• InChI key: ZHMWOVGZCINIHW-FTYOSCRSSA-N

Description

General description

Inhibits α-glucosidase activity in mammals, snails, sweet almonds and yeast. An irreversible, potent, and specific inhibitor of glucocerebrosidase in cultured neurons. Has also been shown to inhibit α-glucosidase from yeast, and rabbit intestinal sucrase-isomaltase complex.

Biochem/physiol Actions

Cell permeable: no

Primary Target
α-glucosidase

Product does not compete with ATP.

Reversible: no

Preparation Note

Unstable in solution; reconstitute just prior to use.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable