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218775

Castanospermine, Castanospermum australe

Plant alkaloid inhibitor of several β-glucosidases and α-glucosidases, including those involved in N-linked processing of glycoproteins.

Synonym(s):

Castanospermine, Castanospermum australe, (1S,6S,7R,8aR)-Tetrahydroxyoctahydroindolizine

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Size/SKUAvailabilityPrice
1 mg

Available to ship TODAYfromKuehne + Nagel Sp. z o.o.

PLN 421.00

About This Item

Empirical Formula (Hill Notation):
C8H15NO4
CAS Number:
79831-76-8
Molecular Weight:
189.21
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00017555
Assay:
≥98% (TLC)
Form:
solid
Storage condition:
OK to freeze, desiccated (hygroscopic)

PLN 421.00

Available to ship TODAYDetails

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description

Merck USA index - 14, 1896

Quality Segment

100

assay

≥98% (TLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated (hygroscopic)

color

white

solubility

water: 1 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

N21[C@@H]([C@H]([C@@H]([C@H](C2)O)O)O)[C@H](CC1)O

InChI

1S/C8H15NO4/c10-4-1-2-9-3-5(11)7(12)8(13)6(4)9/h4-8,10-13H,1-3H2/t4-,5-,6+,7+,8+/m0/s1

InChI key

JDVVGAQPNNXQDW-TVNFTVLESA-N

General description

Plant alkaloid inhibitor of several β-glucosidases and α-glucosidases, including those involved in N-linked processing of glycoproteins. Resulting oligosaccharides are primarily Glu3Man7-9(GlcNAc)2. Reduces bFGF induced angiogenesis in mice. Inhibits endothelial cell migration and invasion of basement membrane. Exhibits anti-viral properties. Typically used at 1-10 µg/ml.

Biochem/physiol Actions

Cell permeable: no
Primary Target
β-glucosidases
Product does not compete with ATP.
Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Ahmed, S.P., et al. 1995. Biochem. Biophys. Res. Commun. 208, 267.
Pili, R., et al. 1995. Cancer Res.55, 2920.
Walker, B.D., et al. 1987. Proc. Natl. Acad. Sci. USA84, 8120.
Pan, Y.T., et al. 1983. Biochemistry22, 3975.
Saul, R., et al. 1983. Arch. Biochem. Biophys. 221, 593.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

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Castanospermine, Castanospermum australe Plant alkaloid inhibitor of several β-glucosidases and α-glucosidases, including those involved in N-linked processing of glycoproteins.

Sigma-Aldrich

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Sigma-Aldrich

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Sigma-Aldrich

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Pterostilbene, Pterocarpus marsupium

Vincristine Sulfate, Apocynaceae sp. Indole alkaloid that binds to tubulin, inhibiting formation of microtubules.

Sigma-Aldrich

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Vincristine Sulfate, Apocynaceae sp.

form

solid

form

solid

form

solid

form

solid

assay

≥98% (TLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥98% (TLC)

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage condition

OK to freeze, desiccated (hygroscopic)

storage condition

OK to freeze

storage condition

OK to freeze, protect from light

storage condition

OK to freeze

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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