1.07071

Neotame

EMPROVE^® ESSENTIAL, NF

• Synonym(s): N-[N-(3,3-Dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester
• Empirical Formula (Hill Notation): C₂₀H₃₀N₂O₅
• CAS Number: 165450-17-9
• Molecular Weight: 378.46
• Beilstein: 8352678
• MDL number: MFCD09039056
• UNSPSC Code: 85151701

Properties

• grade: GMP; Halal; Kosher
• Quality Level: 500
• Agency: NF
• description: GMO free
• product line: EMPROVE^® ESSENTIAL
• form: fine powder
• mp: 80-83 °C
• application(s): pharmaceutical; solid formulation
• storage temp.: 15-25°C
• SMILES string: COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NCCC(C)(C)C
• InChI: 1S/C20H30N2O5/c1-20(2,3)10-11-21-15(13-17(23)24)18(25)22-16(19(26)27-4)12-14-8-6-5-7-9-14/h5-9,15-16,21H,10-13H2,1-4H3,(H,22,25)(H,23,24)/t15-,16-/m0/s1
• InChI key: HLIAVLHNDJUHFG-HOTGVXAUSA-N

Description

General description

As a high-intensity sweetener with an excellent stability and a clean, sugar-like taste profile, neotame is your ideal tool for taste optimization. Due to its exceptional sweetness with a factor 8,000 to 13,000 greater than sucrose and 40-60 greater than aspartame, it is efficient in use and costs.
Neotame is part of our Emprove^® Program and offered with extensive documentation facilitating compliance of your pharma product, full supply chain transparency and risk mitigation. The product withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

From orally disintegrating tablets (ODTs), effervescent tablets to syrups and oral films – neotame can be applied to a wide range of pharmaceutical products and enables safe and heat-stable formulations.

Features and Benefits

• Excellent sugar-like taste profiles
• Masking bitter aftertaste and medical off-notes with ease
• High sweetness potency offers improved cost-efficiency
• Enhanced stability
• Non-cariogenic and suitable for diabetics and patients with phenylketonuria

Packaging

1070711000 / 1 kg / Polyethylene bottle
1070710250 / 250 g / Polyethylene bottle
1070710001 / 3 x 10 g / PE bottles (in cardboard box)

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable