L-034

Levorphanol-D₃ solution

100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

• Empirical Formula (Hill Notation): C₁₇H₂₀D₃NO
• CAS Number: 53447-08-8
• Molecular Weight: 260.39
• EC Number: 200-659-6
• UNSPSC Code: 41116107
• NACRES: NA.24

Properties

• grade: certified reference material
• feature: (Snap-N-Spike^®)
• packaging: ampule of 1 mL
• manufacturer/tradename: Cerilliant^®
• drug control: Narcotic Licence Schedule A (Switzerland); estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)
• concentration: 100 μg/mL in methanol
• format: single component solution
• storage temp.: −20°C
• SMILES string: OC1=CC([C@@]2(CCCC3)[C@]3([H])[C@H](N(C([2H])([2H])[2H])CC2)C4)=C4C=C1
• InChI: 1S/C17H23NO/c1-18-9-8-17-7-3-2-4-14(17)16(18)10-12-5-6-13(19)11-15(12)17/h5-6,11,14,16,19H,2-4,7-10H2,1H3/t14-,16+,17+/m0/s1/i1D3
• InChI key: JAQUASYNZVUNQP-ZHFAENJZSA-N

Description

General description

A Certified Spiking Solution^® suitable for use in clinical toxicology, forensic analysis, urine drug testing, or prescription monitoring as an internal standard to quantitate levorphanol levels in urine or blood or for isotope dilution methods by LC-MS/MS or GC/MS. Levorphanol is an opiate drug sold under the trade name Levo-Dromoran to treat severe pain.

Application

• Forensic toxicology: Levorphanol-D₃ was employed as an internal standard in the development of an enantioselective high-performance liquid chromatography-tandem mass spectrometry method. This method quantitatively determines methorphan and its O-demethylated metabolite in human blood, with applications to post-mortem samples. This study underscores the significance of stable isotope-labeled Levorphanol in enhancing the precision and reliability of forensic toxicology analyses (Lo Faro et al., 2023).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS02,GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H225,H301 + H311 + H331,H370
• Precautionary Statements: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Target Organs: Eyes
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 1
• Flash Point(F): 49.5 °F
• Flash Point(C): 9.7 °C