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880670P

Avanti

C8 PEG750 Ceramide

Avanti Research™ - A Croda Brand 880670P, powder

Synonym(s):

N-octanoyl-sphingosine-1-{succinyl[methoxy(polyethylene glycol)750]}

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About This Item

CAS Number:
212116-76-2
UNSPSC Code:
12352211
NACRES:
NA.25

form

powder

packaging

pkg of 1 × 25 mg (880670P-25mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 880670P

shipped in

dry ice

storage temp.

−20°C

SMILES string

O=C(CCC(OC[C@]([H])(NC(CCCCCCC)=O)[C@]([H])(O)/C=C/CCCCCCCCCCCCC)=O)OOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC.C=C

General description

Ceramide is one of the products of sphingolipid metabolism. The ceramides differ in their acyl chain length.

Application

C8 PEG750 Ceramide has been used in ceramide liposome formulation to test a method for pH-dependent fusion between liposomes and cellular membranes using a pH low insertion peptide. It is also suitable for use in nanoliposomal formulation.

Biochem/physiol Actions

Poly-ethylene glycol (PEG) conjugated to ceramides are applicable as liposomal carriers, enclosing drug molecules. They are known to increase the circulation longevity of the drug due to its neutral surface electrostatic charge. This is inferred to decrease the negative surface charge of the liposomes preventing the release of positively charged encapsulated drug molecule.

Packaging

5 mL Amber Glass Screw Cap Vial (880670P-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Lan Yao et al.
Journal of controlled release : official journal of the Controlled Release Society, 167(3), 228-237 (2013-02-19)
We develop a method for pH-dependent fusion between liposomes and cellular membranes using pHLIP® (pH Low Insertion Peptide), which inserts into lipid bilayer of membrane only at low pH. Previously we establish the molecular mechanism of peptide action and show
Pavan P Adiseshaiah et al.
Cancer letters, 337(2), 254-265 (2013-05-15)
Autophagy, a catabolic survival pathway, is gaining attention as a potential target in cancer. In human liver and colon cancer cells, treatment with an autophagy inducer, nanoliposomal C6-ceramide, in combination with the autophagy maturation inhibitor, vinblastine, synergistically enhanced apoptotic cell
Xin Liu et al.
Blood, 116(20), 4192-4201 (2010-07-31)
The natural killer (NK) type of aggressive large granular lymphocytic (LGL) leukemia is a fatal illness that pursues a rapid clinical course. There are no effective therapies for this illness, and pathogenetic mechanisms remain undefined. Here we report that the
M S Webb et al.
Biochimica et biophysica acta, 1372(2), 272-282 (1998-07-24)
Poly(ethylene glycol) (PEG) conjugated lipids have been used to increase the circulation longevity of liposomal carriers encapsulating therapeutic compounds. PEG is typically conjugated to distearoylphosphatidylethanolamine (DSPE) via a carbamate linkage that results in a net negative charge on the phosphate
Michal Levy et al.
IUBMB life, 62(5), 347-356 (2010-03-12)
In mammals, ceramide, a key intermediate in sphingolipid metabolism and an important signaling molecule, is synthesized by a family of six ceramide synthases (CerS), each of which synthesizes ceramides with distinct acyl chain lengths. There are a number of common

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