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360333

Sodium phosphonoformate tribasic hexahydrate

98%

Synonym(s):

Foscarnet, Phosphonoformic acid trisodium salt hexahydrate

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About This Item

Linear Formula:

Na₂O₃PCO₂Na · 6H₂O

CAS Number:

Molecular Weight:

300.04

MDL number:

PubChem Substance ID:

Assay

98%

SMILES string

O.O.O.O.O.O.[Na+].[Na+].[Na+].[O-]C(=O)P([O-])([O-])=O

InChI

1S/CH3O5P.3Na.6H2O/c2-1(3)7(4,5)6;;;;;;;;;/h(H,2,3)(H2,4,5,6);;;;6*1H2/q;3*+1;;;;;;/p-3

InChI key

ILRVASBWNRYBFD-UHFFFAOYSA-K

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Contrasting effects of W781V and W780V mutations in helix N of herpes simplex virus 1 and human cytomegalovirus DNA polymerases on antiviral drug susceptibility.

Jocelyne Piret et al.

Journal of virology, 89(8), 4636-4644 (2015-02-13)

DNA polymerases of the Herpesviridae and bacteriophage RB69 belong to the α-like DNA polymerase family. In spite of similarities in structure and function, the RB69 enzyme is relatively resistant to foscarnet, requiring the mutation V478W in helix N to promote

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