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161454

Sigma-Aldrich

5-(p-Methylphenyl)-5-phenylhydantoin

≥99%

Synonym(s):

5-(4-Methylphenyl)-,5-phenylimidazolidine-2,4-dione, 5-Phenyl-5-(p-tolyl)hydantoin, MPPH, NSC 32105

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About This Item

Empirical Formula (Hill Notation):
C16H14N2O2
CAS Number:
51169-17-6
Molecular Weight:
266.29
EC Number:
257-028-3
MDL number:
MFCD00005263
UNSPSC Code:
12352100
PubChem Substance ID:
24849929

Assay

≥99%

form

powder

mp

225-226 °C (lit.)

solubility

soluble 50 mg/mL, clear to slightly hazy, colorless to light yellow (DMF:HCl(2:1))

SMILES string

Cc1ccc(cc1)C2(NC(=O)NC2=O)c3ccccc3

InChI

1S/C16H14N2O2/c1-11-7-9-13(10-8-11)16(12-5-3-2-4-6-12)14(19)17-15(20)18-16/h2-10H,1H3,(H2,17,18,19,20)

InChI key

WPAPSGQWYNPWCZ-UHFFFAOYSA-N

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Application

5-(p-Methylphenyl)-5-phenylhydantoin was used as internal standard in quantitative determination of phenytoin in brain microdialysate, saliva and blood from human samples by GC-MS method . It was used in DMD-test to determine chromatographic properties of C8- or C18-bonded phases for clinical and forensic toxicological screening.
Reactant for synthesis of N-chlorohydantoins

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Warning

Hazard Statements

H302,H351,H361

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2 - Repr. 2

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A simple test to characterise C8/C18-bonded phases, particularly for toxicological screening.
Daldrup T and Kardel B.
Chromatographia, 18(2), 81-83 (1984)
T M Hassell et al.
Epilepsia, 25(5), 556-563 (1984-10-01)
The metabolism of sodium phenytoin (PHT) in the cat was studied by gas-liquid chromatographic analyses of the drug and its metabolites extracted from plasma, urine, and feces during a 5-month course of daily oral administration. Plasma PHT levels of 15-18
Jean-Baptiste Rivière et al.
Nature genetics, 44(8), 934-940 (2012-06-26)
Megalencephaly-capillary malformation (MCAP) and megalencephaly-polymicrogyria-polydactyly-hydrocephalus (MPPH) syndromes are sporadic overgrowth disorders associated with markedly enlarged brain size and other recognizable features. We performed exome sequencing in 3 families with MCAP or MPPH, and our initial observations were confirmed in exomes
Helena Fels et al.
Forensic science international, 277, e30-e35 (2017-05-17)
In this study, two fatalities associated with the synthetic opioids AH-7921 and MT-45 are reported. Within the last few years, both compounds have emerged on the recreational drug market and are sold as "research chemicals" on the internet. In the
M Riedmann et al.
Therapeutic drug monitoring, 3(4), 397-413 (1981-01-01)
Specific antiepileptic drug (AED) concentrations in serum are believed to cause therapeutic effects in individual patients. Communication between the clinician and the laboratory performing the drug level determinations is therefore essential for safe and effective medication. The now common practice
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