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157481

Sigma-Aldrich

4-Nitrochalcone

99%

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About This Item

Linear Formula:
O2NC6H4CH=CHCOC6H5
CAS Number:
1222-98-6
Molecular Weight:
253.25
EC Number:
214-949-5
MDL number:
MFCD00007382
UNSPSC Code:
12352100
PubChem Substance ID:
24849682
NACRES:
NA.22

Assay

99%

form

solid

mp

158-160 °C (lit.)

functional group

ketone
nitro
phenyl

SMILES string

[O-][N+](=O)c1ccc(\C=C\C(=O)c2ccccc2)cc1

InChI

1S/C15H11NO3/c17-15(13-4-2-1-3-5-13)11-8-12-6-9-14(10-7-12)16(18)19/h1-11H/b11-8+

InChI key

WDZGGAFMGIOIQS-DHZHZOJOSA-N

General description

Mutagenic activity of 4-nitrochalcone on two strains of Salmonella typhimurium (TA98 and TA100) with and without rat liver microsomal and cytosolic enzymes has been tested.

Application

4-Nitrochalcone was used in the synthesis of 2,3-dibromo-4-nitrochalcone.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
STBJ9896
STBF3006V
S24981
10410CE
14823CU

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Synthesis and Photochromic Properties of New Heterocyclic Derivatives of 1, 3-Diazabicyclo [3.1. 0] Hex-3-Ene.
Mahmoodi NO, et al.
J. Chin. Chem. Soc., 54(3), 635-641 (2007)
K A Rashid et al.
Mutation research, 169(3), 71-79 (1986-03-01)
31 p-monosubstituted chalcones (E-1, 3-diphenylpropene-1-one) and the corresponding oxides (E-1-benzoyl-2-phenyloxirane) were tested for mutagenic activity on two strains of Salmonella typhimurium (TA98 and TA100) with and without rat liver microsomal and cytosolic enzymes. Highest mutagenicity (3.0 revertants/nmole in either strain)
João Paulo Assolini et al.
European journal of pharmacology, 884, 173392-173392 (2020-08-01)
The Leishmaniasis treatment currently available involves some difficulties, such as high toxicity, variable efficacy, high cost, therefore, it is crucial to search for new therapeutic alternatives. Over the past few years, research on new drugs has focused on the use

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