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SML3476

Sigma-Aldrich

Brivaracetam

≥98% (HPLC)

Synonym(s):

(αS,4R)-α-Ethyl-2-oxo-4-propyl-1-pyrrolidineacetamide, (2S)-2-[(4R)-2-Oxo-4-propylpyrrolidin-1-yl]butanamide, (S)-2-((R)-2-Oxo-4-propylpyrrolidin-1-yl)butanamide, UCB 34714, UCB-34714, UCB34714

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About This Item

Empirical Formula (Hill Notation):
C11H20N2O2
CAS Number:
357336-20-0
Molecular Weight:
212.29
MDL number:
MFCD25976668
UNSPSC Code:
12352200
NACRES:
NA.77
Pricing and availability is not currently available.

Quality Level

100

Assay

≥98% (HPLC)

form

powder

drug control

USDEA Schedule V

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

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Biochem/physiol Actions

Brivaracetam shows approximately 10 times greater potency than levetiracetam (Keppra)*; pIC50 at LBS = 7.0; inhibits audiogenic seizures in seizure-prone mice (ED50 = 14 μmol/kg) and is also effective in other animal models of epilepsy. Brivaracetam is used as an anticonvulsant (antiepileptic) for seizure treatment.
Orally active levetiracetam analog with higher synaptic vesicle protein 2A (SV2A) affinity and >10 times greater in vivo antiseizure efficay.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000319117
0000319116
0000258072

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Brivaracetam attenuates pain behaviors in a murine model of neuropathic pain
Molecular Pain (2019)
Brivaracetam is superior to levetiracetam in a rat model of post-hypoxic myoclonus
Journal of neural transmission (Vienna, Austria : 1996), 114(12), 1547-1551 (2007)
Discovery of 4-substituted pyrrolidone butanamides as new agents with significant antiepileptic activity
Journal of medicinal chemistry, 47(3), 530-549 (2004)

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