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SAB4200197

Sigma-Aldrich

Anti-Periostin antibody,Mouse monoclonal

clone 47, purified from hybridoma cell culture

Synonym(s):

Periostin Antibody, Periostin Antibody - Monoclonal Anti-Periostin antibody produced in mouse, Anti-OSF2, Anti-Osteoblast specific factor 2, Anti-PDLPOSTN, Anti-POSTN

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

conjugate

unconjugated

antibody form

purified from hybridoma cell culture

antibody product type

primary antibodies

clone

47, monoclonal

form

buffered aqueous solution

mol wt

antigen ~88 kDa

species reactivity

human

concentration

~1.0 mg/mL

technique(s)

western blot: 2-4 μg/mL using whole extracts of HEK-293T cells over expressing human Periostin

isotype

IgG1

UniProt accession no.

Q15063

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... POSTN(10631)

General description

Periostin (POSTN) is also known as osteoblast-specific factor-2. It is a 90 kDa protein expressed in the extracellular matrix and bones. POSTN is an adhesive glycoprotein. The gene encoding this protein is localized on human chromosome 13q13.3.

Immunogen

human Periostin recombinant protein. The human protein shares 87% homology with the mouse protein.

Application

Monoclonal Anti-Periostin antibody produced in mouse has been used to develop a periostin imaging PET probe.

Biochem/physiol Actions

Periostin (POSTN) has a role in the differentiation and cell adhesion of osteogenic cells. It functions as a biomarker of T-helper cells type 2-mediated inflammatory diseases. The protein has been associated with various cancers. POSTN is involved in epithelial-mesenchymal transition and extracellular matrix degradation.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Functional role of periostin in development and wound repair: implications for connective tissue disease.
Hamilton D W.
Journal of Cell Communication and Signaling, 2(1-2), 9-9 (2008)
Mechanism of Periostin Production in Human Bronchial Smooth Muscle Cells.
Makita K, et al.
International Archives of Allergy and Immunology, 175(1-2), 26-35 (2018)
Bone marrow mesenchymal stem cells promote head and neck cancer progression through Periostin?mediated phosphoinositide 3?kinase/Akt/mammalian target of rapamycin.
Liu C, et al.
Cancer Science, 109(3), 688-698 (2018)
Deepraj Ghosh et al.
Journal of cell science, 133(2) (2020-01-15)
Mesenchymal stem cells (MSCs) are essential for the regenerative process; however, biological aging and environmental stress can induce senescence - an irreversible state of growth arrest - that not only affects the behavior of cells but also disrupts their ability
Imaging of secreted extracellular periostin, an important marker of invasion in the tumor microenvironment in esophageal cancer.
Heidari P, et al.
Journal of Nuclear Medicine, 56(8), 1246-1246 (2015)
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