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S6942
Staurosporine
from Streptomyces sp., >98% (HPLC), solution, protein kinase inhibitor
Synonym(s):
Antibiotic AM-2282
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Product Name
Staurosporine solution from Streptomyces sp., Ready Made Solution, 1 mM in DMSO (100 μg/214 μL), 0.2 μm filtered
Quality Level
sterility
0.2 μm filtered
Assay
>98% (HPLC)
concentration
1 mM in DMSO (100 μg/214 μL)
technique(s)
cell culture | mammalian: suitable
antibiotic activity spectrum
fungi
Mode of action
enzyme | inhibits
shipped in
wet ice
storage temp.
−20°C
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General description
Chemical structure: indol derivative
Application
Staurosporine solution from Streptomyces sp. was used to study the effect of PKC inhibition on signaling mediated by angiotensin II.3 It was used to induce cell death in Jurkat cells.4
Biochem/physiol Actions
Potent cell-permeable inhibitor of protein kinase C. Induces apoptosis in Jurkat cells.
Potent inhibitor of phospholipid/calcium-dependent protein kinase. Inhibits the upregulation of VEGF expression in tumor cells.
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
188.6 °F - closed cup
Flash Point(C)
87 °C - closed cup
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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What concentration of Staurosporin is used for the release of microparticles from apoptotic cells?
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Staurosporin can induce apopotosis in Jurkat cells (106/ml) at 1 ug/ml following a 1-2 hour incubation at 37°C. For the release of microparticles from apoptotic Jurkat cells, use staurosporin at 1 uM for 107 cells/ml. Please see the reference below for further details. Apoptosis 15(5):586, 2010.
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