Skip to Content
Merck
All Photos(1)

Documents

M7316

Sigma-Aldrich

Monoamine Oxidase A human

recombinant, expressed in baculovirus infected BTI insect cells

Synonym(s):

MAO-A, MAOA

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Enzyme Commission number:
1.4.3.4 (BRENDA, IUBMB)
MDL number:
MFCD04040932
UNSPSC Code:
12352204
NACRES:
NA.54

recombinant

expressed in baculovirus infected BTI insect cells

Quality Level

100

form

liquid

packaging

vial of ~2.5 mg

UniProt accession no.

P21397

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... MAOA(4128)

General description

Monoamine Oxidase A contains binding sites for 8α-S-cysteinyl-FAD.
Monoamine oxidases metabolize biogenic amines in the central nervous system and the peripheral tissue.

Application

Monoamine Oxidase A has been used in a study to assess abnormal behavior in a large kindred of males where a deficiency of enzymatic activity of monamine oxidase A was found. It has also been used in a study to investigate an association between smoking and the inhibition of MAOA.

Biochem/physiol Actions

MAO′s are proteins of the mitochondrial membrane. These enzymes are responsible for catalyzing oxidative deamination of endo- and xenobiotic amines. Substrate specificity differs for each isozyme.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

J S Fowler et al.
Proceedings of the National Academy of Sciences of the United States of America, 93(24), 14065-14069 (1996-11-26)
Several studies have documented a strong association between smoking and depression. Because cigarette smoke has been reported to inhibit monoamine oxidase (MAO) A in vitro and in animals and because MAO A inhibitors are effective antidepressants, we tested the hypothesis
Ryuichi Harada et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 62(2), 253-258 (2020-07-11)
Reactive astrocytes play a key role in the pathogenesis of various neurodegenerative diseases. Monoamine oxidase-B (MAO-B) is one of the promising targets for the imaging of astrogliosis in the human brain. A novel selective and reversible MAO-B tracer, (S)-(2-methylpyrid-5-yl)-6-[(3-18F-fluoro-2-hydroxy)propoxy]quinoline (18F-SMBT-1)
Marcus A Maher et al.
Analytical and bioanalytical chemistry, 408(3), 695-703 (2015-11-18)
The need for rapid and cost-effective pre-screening protocols of the toxicological response of the vast array of emerging nanoparticle types is apparent and the emerging consensus on the paradigm of oxidative stress by generation of intracellular reactive oxygen species as
Wenping Wang et al.
Antioxidants (Basel, Switzerland), 10(10) (2021-10-24)
Neurotransmitter catecholamines (dopamine, epinephrine, and norepinephrine) are liable to undergo oxidation, which copper is deeply involved in. Catecholamine oxidation-derived neurotoxicity is recognized as a pivotal pathological mechanism in neurodegenerative diseases. Glutamate, as an excitatory neurotransmitter, is enriched in the brain
Moussa B H Youdim et al.
Nature reviews. Neuroscience, 7(4), 295-309 (2006-03-23)
Monoamine oxidase inhibitors were among the first antidepressants to be discovered and have long been used as such. It now seems that many of these agents might have therapeutic value in several common neurodegenerative conditions, independently of their inhibition of
View All Related Papers

Articles

Serotonin Synthesis & Metabolism

Serotonin is stored in cells and metabolized by MAO, influencing CNS, GI, and platelet functions.

Serotonin Synthesis & Metabolism

Serotonin is stored in cells and metabolized by MAO, influencing CNS, GI, and platelet functions.

Serotonin Synthesis & Metabolism

Serotonin is stored in cells and metabolized by MAO, influencing CNS, GI, and platelet functions.

Serotonin Synthesis & Metabolism

Serotonin is stored in cells and metabolized by MAO, influencing CNS, GI, and platelet functions.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service