I3766

Isoliquiritigenin

powder

• Synonym(s): (E)-1-(2,4-Dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one, 4,2′,4′-Trihydroxychalcone
• Empirical Formula (Hill Notation): C₁₅H₁₂O₄
• CAS Number: 961-29-5
• Molecular Weight: 256.25
• Beilstein: 1914296
• MDL number: MFCD00075907
• UNSPSC Code: 41106305
• PubChem Substance ID: 24278037
• NACRES: NA.77

Properties

• form: powder
• Quality Level: 200
• color: yellow to orange
• solubility: H₂O: <0.1 mg/mL; methanol: 10 mg/mL; DMSO: 20 mg/mL
• storage temp.: 2-8°C
• SMILES string: Oc1ccc(cc1)\C=C\C(=O)c2ccc(O)cc2O
• InChI: 1S/C15H12O4/c16-11-4-1-10(2-5-11)3-8-14(18)13-7-6-12(17)9-15(13)19/h1-9,16-17,19H/b8-3+
• InChI key: DXDRHHKMWQZJHT-FPYGCLRLSA-N
• Gene Information: rat ... Alox5(25290)

Description

General description

Isoliquiritigenin is an aromatic ketone and belongs to the chalcone group of compound. It is derived from licorice and is a component in medicine and food.

Application

Isoliquiritigenin has been used:

• as a bone morphogenetic protein (BMP) agonist in zebrafish embryos
• as a guanylyl cyclase activator in zebrafish embryos
• to test its antitumor and antiviral effects against Epstein-Barr virus-associated gastric carcinoma

Biochem/physiol Actions

Isoliquiritigenin is a soluble guanylyl cyclase activator and possesses antitumor activity. It also possesses antioxidant, antiplatelet and estrogenic properties.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Caution

Photosensitive, hygroscopic

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves