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Key Documents

H4644

Sigma-Aldrich

Hypercalcemia of malignancy factor 1-40 human

≥95% (HPLC), suitable fo drug transporter assays

Synonym(s):

Ala-Val-Ser-Glu-His-Gln-Leu-Leu-His-Asp-Lys-Gly-Lys-Ser-Ile-Gln-Asp-Leu-Arg-Arg-Arg-Phe-Phe-Leu-His-His-Leu-Ile-Ala-Glu-Ile-His-Thr-Ala-Glu-Ile-Arg-Ala-Thr-Ser, PTH-Like Adenylate Cyclase Stimulating Protein, PTHrP (1-40), Parathyroid hormone-related protein (1-40)

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About This Item

Empirical Formula (Hill Notation):
C207H334N66O58
CAS Number:
120298-73-9
Molecular Weight:
4675.27
MDL number:
MFCD00081712
UNSPSC Code:
12352201
NACRES:
NA.26

product name

Hypercalcemia of malignancy factor 1-40 human, ≥95% (HPLC)

Quality Level

200

Assay

≥95% (HPLC)

form

solid

technique(s)

drug transporter assay: suitable

UniProt accession no.

P12272

storage temp.

−20°C

Gene Information

human ... PTHLH(5744)

Amino Acid Sequence

Ala-Val-Ser-Glu-His-Gln-Leu-Leu-His-Asp-Lys-Gly-Lys-Ser-Ile-Gln-Asp-Leu-Arg-Arg-Arg-Phe-Phe-Leu-His-His-Leu-Ile-Ala-Glu-Ile-His-Thr-Ala-Glu-Ile-Arg-Ala-Thr-Ser

Biochem/physiol Actions

Hypercalcemia of malignancy factor fragment 1-40 human is a parathyroid hormone-like protein (PLP) fragment used to study parathyroid hormone-related signaling pathways.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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C Cataisson et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 15(11), 2129-2139 (2000-11-25)
Parathyroid hormone-related protein (PTHrP) is the main mediator of humoral hypercalcemia of malignancy (HHM) and it is produced by many tumors, including breast cancers. Breast epithelial cells as well as breast cancer tumors and cell lines have been reported as
J M Moseley et al.
Proceedings of the National Academy of Sciences of the United States of America, 84(14), 5048-5052 (1987-07-01)
A protein with biological activities similar to parathyroid hormone (PTH) has been purified from serum-free culture medium obtained from a human lung cancer cell line (BEN). A major protein band of 18 kDa was obtained on NaDodSO4/polyacrylamide gels, with faint
Parathyroid hormone-related peptide and primary hyperparathyroidism.
Testini M, Gurrado A, et al.
Frontiers in Bioscience, 2, 299-312 (2010)
P Esbrit et al.
The Journal of endocrinology, 166(1), 11-20 (2000-06-17)
Parathyroid hormone (PTH)-related protein (PTHrP) is the main factor responsible for humoral hypercalcemia of malignancy. Both PTH and PTHrP bind to the common type I PTH/PTHrP receptor (PTHR), thereby activating phospholipase C and adenylate cyclase through various G proteins, in
T J Rosol et al.
Domestic animal endocrinology, 8(4), 499-507 (1991-10-01)
The effects of transforming growth factor-alpha (TGF alpha) were determined on the ability of parathyroid hormone (PTH) or parathyroid hormone-related protein (PTHrP) to stimulate bone resorption and adenylate cyclase in vitro. Bovine PTH-(1-34) and human PTHrP-(1-34) were equipotent in their
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