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A9512

Sigma-Aldrich

L-(−)-Norepinephrine (+)-bitartrate salt monohydrate

≥99% (TLC), solid, vasoconstrictor

Synonym(s):

L-(−)-Noradrenaline (+)-bitartrate salt monohydrate

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About This Item

Empirical Formula (Hill Notation):
C8H11NO3 · C4H6O6 · H2O
CAS Number:
108341-18-0
Molecular Weight:
337.28
MDL number:
MFCD00150449
UNSPSC Code:
12352200
PubChem Substance ID:
57653897
NACRES:
NA.77

product name

L-(−)-Norepinephrine (+)-bitartrate salt monohydrate, ≥99%, solid

Quality Level

200

Assay

≥99%

form

solid

color

white

solubility

H2O: 46 mg/mL

SMILES string

O.O[C@H]([C@@H](O)C(O)=O)C(O)=O.NC[C@H](O)c1ccc(O)c(O)c1

InChI

1S/C8H11NO3.C4H6O6.H2O/c9-4-8(12)5-1-2-6(10)7(11)3-5;5-1(3(7)8)2(6)4(9)10;/h1-3,8,10-12H,4,9H2;1-2,5-6H,(H,7,8)(H,9,10);1H2/t8-;1-,2-;/m01./s1

InChI key

LNBCGLZYLJMGKP-LUDZCAPTSA-N

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Application

L-(-)-Norepinephrine (+)-bitartrate salt monohydrate has been used:
  • to infuse dogs to form a intracellular lipid accumulation model
  • to analyse the signaling involved in the up-regulation of monocarboxylate transporter 2 (MCT2) expression in cultured cortical neuron
  • in neurochemical preparation to study the response of gram-negative and gram-positive bacteria to norepinephrine
  • to study the roles of peripheral hormones on thyroid activity of turtles

Biochem/physiol Actions

Norepinephrine bitartrate plays an important role in in vivo and in vitro development of pathogenic and indigenous bacteria. It acts as a vasoconstrictor and adrenergic neurotransmitter.

Caution

Light sensitive

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H300 + H310

Hazard Classifications

Acute Tox. 1 Dermal - Acute Tox. 2 Oral

Storage Class Code

6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Noradrenaline enhances the expression of the neuronal monocarboxylate transporter MCT2 by translational activation via stimulation of PI3K/Akt and the mTOR/S6K pathway
Chenal J and Pellerin L
Journal of Neurochemistry, 102(2), 389-397 (2007)
Roles of thyroid, adrenal and pancreatic hormones on thyroid activity of the soft-shelled turtles Lissemys punctata punctata Bonnoterre
Ray PP, et al.
Folia Biologica (Krakow.), 54(3-4), 93-102 (2006)
Stimulation of bacterial growth by heat-stable, norepinephrine-induced autoinducers
Freestone PPE, et al.
FEMS Microbiology Letters, 172(1), 53-60 (1999)
Jonathan E Wingo et al.
Journal of applied physiology (Bethesda, Md. : 1985), 109(5), 1301-1306 (2010-08-14)
Sweat rate (SR) is reduced in locally cooled skin, which may result from decreased temperature and/or parallel reductions in skin blood flow. The purpose of this study was to test the hypotheses that decreased skin blood flow and decreased local
Gillian D Pullinger et al.
Veterinary research, 41(5), 68-68 (2010-07-09)
Salmonella enterica serovar Typhimurium is an animal and zoonotic pathogen of worldwide importance. In pigs, transport and social stress are associated with reactivation and spread of Salmonella Typhimurium infection. The stress-related catecholamine norepinephrine (NE) has been reported to activate growth
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