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D201863

Sigma-Aldrich

1,4-Dioxane

ReagentPlus®, ≥99%, contains ≤25 ppm BHT as stabilizer

Synonym(s):

Diethylene oxide, Dioxane

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About This Item

Empirical Formula (Hill Notation):
C4H8O2
CAS Number:
123-91-1
Molecular Weight:
88.11
Beilstein:
102551
EC Number:
204-661-8
MDL number:
MFCD00006571
UNSPSC Code:
12352005
PubChem Substance ID:
329798726
NACRES:
NA.21
Assay:
≥99%
technique(s):
thin layer chromatography (TLC): suitable
bp:
100-102 °C (lit.)
vapor pressure:
27 mmHg ( 20 °C)
40 mmHg ( 25 °C)
Pricing and availability is not currently available.

vapor density

3 (vs air)

Quality Level

100

vapor pressure

27 mmHg ( 20 °C)
40 mmHg ( 25 °C)

product line

ReagentPlus®

Assay

≥99%

form

liquid

autoignition temp.

356 °F

contains

≤25 ppm BHT as stabilizer

expl. lim.

22 %

technique(s)

thin layer chromatography (TLC): suitable

refractive index

n20/D 1.422 (lit.)

pH

6.0-8 (20 °C, 500 g/L)

bp

100-102 °C (lit.)

mp

10-12 °C (lit.)

density

1.034 g/mL at 25 °C (lit.)

SMILES string

C1COCCO1

InChI

1S/C4H8O2/c1-2-6-4-3-5-1/h1-4H2

InChI key

RYHBNJHYFVUHQT-UHFFFAOYSA-N

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Application

1,4-Dioxane can be used as a solvent:
  • To synthesize 1,3-diamines and amino alcohols via 2-azaallyl anion benzylic ring-opening of aziridines.
  • In the RAFT polymerization of acryclic acid[1].
  • In the synthesis of cross-linked triblock copolymer hydrogels[2].

Legal Information

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

Signal Word

Danger

Hazard Statements

H225,H319,H335,H350

Hazard Classifications

Carc. 1B - Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

Target Organs

Respiratory system

Supplementary Hazards

EUH019,EUH066

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

51.8 °F - closed cup

Flash Point(C)

11 °C - closed cup

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Certificates of Analysis (COA)

Lot/Batch Number
SHBS1223
SHBQ6212
SHBR2130
STBK9814
SHBP3862

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High-toughness polycation cross-linked triblock copolymer hydrogels
Chen Y, et al.
Macromolecules, 50, 3637-3646 (2017)
Photoactive rose bengal-based latex via RAFT emulsion polymerization-induced self-assembly
Boussiron C, et al.
Open Journal of Polymer Chemistry, 12, 134-147 (2021)
Yimu Zhao et al.
Advanced healthcare materials, 8(5), e1801187-e1801187 (2019-02-10)
Due to escalating drug developmental costs and limitations of cardiotoxicity screening, there is an urgent need to develop robust in vitro 3D tissue culture platforms that can both facilitate the culture of human cardiac tissues and provide noninvasive functional readouts
Christof Aellig et al.
ChemSusChem, 5(9), 1737-1742 (2012-07-05)
The dehydration of D-fructose to 5-hydroxymethylfurfural was studied under single-phase conditions in the low boiling solvent 1,4-dioxane at moderate temperatures in the presence of the solid acid-catalyst Amberlyst-15. The reaction was first examined and optimized under batch conditions, where it
Alkene trifluoromethylation coupled with C-C bond formation: construction of trifluoromethylated carbocycles and heterocycles.
Hiromichi Egami et al.
Angewandte Chemie (International ed. in English), 52(14), 4000-4003 (2013-02-27)
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